Bactrim and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bactrim (sulfamethoxazole; trimethoprim) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include injection site extravasation among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Bactrim and Ziac. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

On Jul, 26, 2026

28 people who take Bactrim and Ziac together, and have interactions are studied.

What are the common drug interactions of Bactrim and Ziac, by gender? *:

female:

Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site haemorrhage (bleeding from injection site)
Kidney infection
Localised infection (infection at the single location)
Malaise (a feeling of general discomfort or uneasiness)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Nausea (feeling of having an urge to vomit)
Nephropathy (damage to or disease of a kidney)
Osteomyelitis chronic (long lasting infection of bone marrow)

male:

Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Myocarditis (inflammation of heart muscle myocardium)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Neuropathy peripheral (surface nerve damage)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pain
Pruritus (severe itching of the skin)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Rash erythematous (redness of the skin)

What are the common drug interactions of Bactrim and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Tarsal tunnel syndrome (a condition that is caused by compression of the tibial nerve or its associated branches as the nerve)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Vasculitis (inflammation of a blood vessel or blood vessels)
Vestibular disorder (disorders of the body's balance (vestibular) system in the inner ear)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Glaucoma (increased fluid pressure in the eye with vision loss)
Neuropathy peripheral (surface nerve damage)

40-49:

Dizziness
Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Anxiety
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood creatinine increased
Blood glucose increased
Bradycardia (abnormally slow heart action)
Burning sensation

50-59:

Chest pain
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Cardiac disorder
Influenza like illness
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Pulmonary congestion (congestion in the lungs)
Thyroid neoplasm (tumour of thyroid)
Abdominal pain upper
Ageusia (loss of taste functions of the tongue)
Asthenia (weakness)

60+:

Nausea (feeling of having an urge to vomit)
Cardiac failure congestive
Pyrexia (fever)
Rash erythematous (redness of the skin)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rigors (an episode of shaking or exaggerated shivering)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug hypersensitivity
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Pain: 5 people, 17.86%
Multiple Myeloma (cancer of the plasma cells): 4 people, 14.29%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 14.29%
Immunodeficiency Common Variable: 3 people, 10.71%
Constipation: 3 people, 10.71%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 10.71%
Vulvovaginal Dryness: 2 people, 7.14%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 7.14%
Nausea (feeling of having an urge to vomit): 2 people, 7.14%
Muscle Spasms (muscle contraction): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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