Belsomra and Restoril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Belsomra (suvorexant) and Restoril (temazepam). Common drug interactions include knee arthroplasty among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Belsomra and Restoril. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Belsomra?

Belsomra has active ingredients of suvorexant. It is often used in insomnia. eHealthMe is studying from 12,961 Belsomra users. Check the latest studies of Belsomra.

What is Restoril?

Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.

On Jul, 28, 2026

23 people who take Belsomra and Restoril together, and have interactions are studied.

Belsomra and Restoril drug interactions.

What are the common drug interactions of Belsomra and Restoril, by gender? *:

female:

Knee arthroplasty
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Somnolence (a state of near-sleep, a strong desire for sleep)
Adverse event
Agitation (state of anxiety or nervous excitement)
Anxiety
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Depression
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Fall

male:

Drug ineffective
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Therapeutic response unexpected
Weight increased
Abnormal dreams
Aggression
Blood sodium increased

What are the common drug interactions of Belsomra and Restoril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Aggression

50-59:

Drug ineffective
Adverse event
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Fall
Hypertension (high blood pressure)
Muscle injury
Muscle twitching
Renal failure (kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Synovial cyst (cyst of joint filled with synovial fluid)

60+:

Drug ineffective
Constipation
Palpitations (feelings or sensations that your heart is pounding or racing)
Knee arthroplasty
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abnormal dreams
Agitation (state of anxiety or nervous excitement)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Headache (pain in head)

What are the existing conditions these people have? *

Sleep Disorder: 6 people, 26.09%
Pain: 4 people, 17.39%
Stress And Anxiety: 2 people, 8.70%
Neuralgia (pain in one or more nerves): 2 people, 8.70%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.70%
Impaired Gastric Emptying: 2 people, 8.70%
Hypotension (abnormally low blood pressure): 2 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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