Benadryl and Akynzeo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Akynzeo (netupitant; palonosetron hydrochloride). Common drug interactions include fatigue among females and neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Akynzeo. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Akynzeo?

Akynzeo has active ingredients of netupitant; palonosetron hydrochloride. eHealthMe is studying from 1,332 Akynzeo users. Check the latest studies of Akynzeo.

On Aug, 04, 2026

34 people who take Benadryl and Akynzeo together, and have interactions are studied.

What are the common drug interactions of Benadryl and Akynzeo, by gender? *:

female:

Fatigue (feeling of tiredness)
Weight increased
Weight decreased
Diarrhoea
Dizziness
Somnolence (a state of near-sleep, a strong desire for sleep)
Cough
Hypotension (abnormally low blood pressure)
Pain
Pain in extremity

male:

Neutropenia (an abnormally low number of neutrophils)
Abdominal pain
Adverse drug reaction
Neoplasm malignant (cancer tumour)
Decreased appetite
Disease progression
Anaemia (lack of blood)
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypercalcaemia (elevated calcium (ca+) level in the blood)

What are the common drug interactions of Benadryl and Akynzeo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Death

40-49:

Hospitalisation

50-59:

Colitis (inflammation of colon)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Weight increased
Cough
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pain
Pain in extremity
Weight decreased
Pain of skin
Abdominal discomfort

60+:

Hypotension (abnormally low blood pressure)
Weight fluctuation
Weight increased
Sedation
Death
Malaise (a feeling of general discomfort or uneasiness)
Dehydration (dryness resulting from the removal of water)
Infusion site pain
Pyrexia (fever)
Abdominal pain upper

What are the existing conditions these people have? *

Stress And Anxiety: 7 people, 20.59%
Pain: 6 people, 17.65%
Cardiomyopathy (weakening of the heart muscle): 6 people, 17.65%
Constipation: 6 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 17.65%
Fever: 6 people, 17.65%
Pleuritic Pain: 6 people, 17.65%
Rashes (redness): 6 people, 17.65%
Cough: 5 people, 14.71%
Hypokalemia (low potassium): 5 people, 14.71%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and Akynzeo?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously