Benadryl and Apriso drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Apriso (mesalamine). Common drug interactions include mucous stools among females and infusion related reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Apriso. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,956 Benadryl users. Check the latest studies of Benadryl.

What is Apriso?

Apriso has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 3,439 Apriso users. Check the latest studies of Apriso.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

45 people who take Benadryl and Apriso together, and have interactions are studied.

What are the common drug interactions of Benadryl and Apriso, by gender? *:

female:

Mucous stools (mucous with stool)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain
Platelet count increased
Rectal discharge (discharge from rectum)
Weight decreased
Abdominal pain
Abdominal pain lower
Abnormal loss of weight
Agitation (state of anxiety or nervous excitement)

male:

Infusion related reaction
Dyspnoea (difficult or laboured respiration)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Neuropathy peripheral (surface nerve damage)
Palpitations (feelings or sensations that your heart is pounding or racing)
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Rash erythematous (redness of the skin)
Rectal haemorrhage (bleeding from anus)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the common drug interactions of Benadryl and Apriso, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug level below therapeutic
Infusion related reaction
Anaemia (lack of blood)
Arthralgia (joint pain)
Cerebrospinal fluid leakage
Dehydration (dryness resulting from the removal of water)
Ependymoma (tumour in the brain)
Epstein-barr virus antibody positive
Hemiplegia (paralysis of one side of the body)
Migraine (headache)

20-29:

Abdominal pain
Constipation
Intestinal obstruction
Ovarian cyst ruptured (tear in fluid filled sac of the ovary)
Postoperative adhesion
Urinary tract infection

30-39:

Antepartum haemorrhage (bleeding from the vagina during pregnancy from the 24th week)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fall
Premature separation of placenta
Skeletal injury (bone and supporting muscle injury)
Upper respiratory tract infection
Viral infection
Drug exposure during pregnancy
Chronic kidney disease
Hepatic infection

40-49:

Heart rate increased
Injection site pain
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Pyrexia (fever)
Anxiety
Asthenia (weakness)
Constipation

50-59:

Abdominal pain upper
Diarrhoea
Fatigue (feeling of tiredness)
Feeling cold
Haematochezia (passage of stools containing blood)
Infusion site bruising
Joint destruction (joint damage)
Peripheral swelling
Postoperative wound infection
Agitation (state of anxiety or nervous excitement)

60+:

Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Blood glucose increased
Blood potassium increased
Blood sodium decreased
Chronic kidney disease
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Erythema (redness of the skin)
Haematocrit decreased

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 19 people, 42.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 11.11%
Rickets (softening of bones): 4 people, 8.89%
Pain: 4 people, 8.89%
Colitis (inflammation of colon): 4 people, 8.89%
Upper Respiratory Tract Infection: 3 people, 6.67%
Seasonal Allergy (allergic condition due to certain season): 3 people, 6.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.67%
Reflux Gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile): 3 people, 6.67%
Inflammation: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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