Benadryl and Borage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Borage (borage). Common drug interactions include abdominal pain among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Borage. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Borage?

Borage has active ingredients of borage. eHealthMe is studying from 272 Borage users. Check the latest studies of Borage.

On Jul, 11, 2026

13 people who take Benadryl and Borage together, and have interactions are studied.

What are the common drug interactions of Benadryl and Borage, by gender? *:

female:

Abdominal pain
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Injury
Pain
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Appendix disorder
Disease recurrence
Drug ineffective
Injection site erythema (redness at injection site)

male:

Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Lip dry
Neoplasm progression (growth of tumour)
Pain
Stomatitis (inflammation of mucous membrane of mouth)
Thirst
Weight decreased
Weight increased
Diarrhoea

What are the common drug interactions of Benadryl and Borage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Injury
Pain
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Appendix disorder

30-39:

n/a

40-49:

n/a

50-59:

Disease recurrence
Throat tightness

60+:

Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Lip dry
Neoplasm progression (growth of tumour)
Pain
Stomatitis (inflammation of mucous membrane of mouth)
Thirst
Weight decreased
Weight increased
Diarrhoea

What are the existing conditions these people have? *

Pancreatic Neuroendocrine Tumor Metastatic: 7 people, 53.85%
Neuroendocrine Tumor: 7 people, 53.85%
Diarrhea: 7 people, 53.85%
Bone Disorder: 7 people, 53.85%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 30.77%
Stress And Anxiety: 3 people, 23.08%
Nausea (feeling of having an urge to vomit): 3 people, 23.08%
Menstruation Irregular: 3 people, 23.08%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 23.08%
Birth Control: 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

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