Benadryl and Diamox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Diamox (acetazolamide). Common drug interactions include gastric haemorrhage among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Diamox. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Diamox?

Diamox has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 4,711 Diamox users. Check the latest studies of Diamox.

On Jul, 09, 2026

69 people who take Benadryl and Diamox together, and have interactions are studied.

What are the common drug interactions of Benadryl and Diamox, by gender? *:

female:

Gastric haemorrhage (bleeding stomach)
Abdominal compartment syndrome (increased pressure in abdomen)
Abdominal pain
Aortic valve stenosis (narrowing of the aortic valve)
Arachnoiditis (neuropathic disease caused by inflammation of the arachnoid)
Depression
Drug ineffective
Acne (skin problems that cause pimples)
Aphthous ulcer (mouth ulcer)
Cataract (clouding of the lens inside the eye)

male:

Anxiety
Asthenia (weakness)
Injection site pain
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Muscular weakness (muscle weakness)
Sedation
Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Hypoaesthesia (reduced sense of touch or sensation)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

What are the common drug interactions of Benadryl and Diamox, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

n/a

10-19:

Anxiety
Pain
Rash
Aortic valve stenosis (narrowing of the aortic valve)
Back pain
Bone disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Disease progression

20-29:

Acne (skin problems that cause pimples)
Aphthous ulcer (mouth ulcer)
Cataract (clouding of the lens inside the eye)
Depression
Heart rate increased
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Oral pain
Uveitis (inflammation of the uvea)
Drug ineffective
Encephalitis (inflammation of the brain)

30-39:

Hypersensitivity
Caecitis (inflammation of the cecum)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Sepsis (a severe blood infection that can lead to organ failure and death)
Headache (pain in head)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Nausea (feeling of having an urge to vomit)
Pain
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus generalised (generalized itching)
Quality of life decreased
Rash macular (small, flat red spots)

50-59:

Cerebrospinal fluid leakage
Drug ineffective
Epistaxis (bleed from the nose)
Head discomfort
Hospitalisation
Injection site discolouration
Injection site haemorrhage (bleeding from injection site)
Neoplasm (tumour)
Peripheral swelling

60+:

General physical health deterioration (weak health status)
Cardiac arrest
Apnoea (suspension of external breathing)
Biliary dilatation
Blood alkaline phosphatase increased
Blood creatinine increased
Blood lactate dehydrogenase increased
Cardiac failure congestive
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Death

What are the existing conditions these people have? *

Uveitis (inflammation of the uvea): 13 people, 18.84%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 13 people, 18.84%
Nausea (feeling of having an urge to vomit): 9 people, 13.04%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 11.59%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 11.59%
Pain: 7 people, 10.14%
High Blood Pressure: 5 people, 7.25%
Stress And Anxiety: 4 people, 5.80%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.80%
Diabetes: 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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