Benadryl and Evoxac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Evoxac (cevimeline hydrochloride). Common drug interactions include cystitis among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Evoxac. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Evoxac?

Evoxac has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 2,028 Evoxac users. Check the latest studies of Evoxac.

On Jul, 06, 2026

75 people who take Benadryl and Evoxac together, and have interactions are studied.

What are the common drug interactions of Benadryl and Evoxac, by gender? *:

female:

Cystitis (inflammation of the wall of the bladder)
Cellulitis (infection under the skin)
Lymphadenopathy (disease or enlargement of lymph nodes)
Urethral stenosis (narrowing of the urethra, may cause decreased urine output)
Headache (pain in head)
Back pain
Stomatitis (inflammation of mucous membrane of mouth)
Foot fracture
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Proteinuria (presence of protein in the urine)

male:

Arthralgia (joint pain)
Bacterial infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gait disturbance
Headache (pain in head)
Somnolence (a state of near-sleep, a strong desire for sleep)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Back injury

What are the common drug interactions of Benadryl and Evoxac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood pressure decreased
Hypotonia (low muscle tone)
Weight increased
Decreased appetite
Dizziness
Headache (pain in head)
Ill-defined disorder
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Nervousness

40-49:

Arthralgia (joint pain)
Headache (pain in head)
Gait disturbance
Pyrexia (fever)
Anxiety
Diarrhoea
Hypophagia (reduced food intake)
Urinary tract infection
Abdominal mass (localized enlargement or swelling in the human abdomen)
Activities of daily living impaired

50-59:

Emotional distress
Epistaxis (bleed from the nose)
Eye infection
Eye pain
Facial bones fracture (bone fracture of face)
Femur fracture
Glossitis (infection of tongue with soreness)
Groin pain
Haemolytic anaemia (anaemia due to haemolysis)
Hyperkeratosis (thickening of the outer layer of the skin)

60+:

Headache (pain in head)
Ear infection
Blood pressure increased
Fluid retention (an abnormal accumulation of fluid in the blood)
Flushing (the warm, red condition of human skin)
Head discomfort
Hyperacusis (disorder in loudness perception)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Photophobia (extreme sensitivity to light)
Psychiatric symptom

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 9 people, 12.00%
Breast Cancer: 9 people, 12.00%
Pain: 8 people, 10.67%
Dry Mouth: 6 people, 8.00%
Stress And Anxiety: 6 people, 8.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 8.00%
Behcet's Syndrome (involves inflammation of the blood vessels): 5 people, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 6.67%
Hypersensitivity: 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and Evoxac?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously