Benadryl and Innohep drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Innohep (tinzaparin sodium). Common drug interactions include nausea among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Innohep. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,956 Benadryl users. Check the latest studies of Benadryl.

What is Innohep?

Innohep has active ingredients of tinzaparin sodium. eHealthMe is studying from 9,243 Innohep users. Check the latest studies of Innohep.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

29 people who take Benadryl and Innohep together, and have interactions are studied.

What are the common drug interactions of Benadryl and Innohep, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased
Blood pressure fluctuation
Cyst (a closed sac)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Dizziness
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Infusion related reaction

male:

Death
Intestinal perforation (complete penetration of the wall of the intestine)
Anxiety
Arthralgia (joint pain)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Depression
Disturbance in attention
Dizziness
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Benadryl and Innohep, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Death
Arthralgia (joint pain)
Headache (pain in head)
Blood pressure fluctuation
Constipation
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Nausea (feeling of having an urge to vomit)
Rash
Vomiting
Alopecia (absence of hair from areas of the body)

50-59:

Intestinal perforation (complete penetration of the wall of the intestine)
Neoplasm malignant (cancer tumour)
Cyst (a closed sac)
Dehydration (dryness resulting from the removal of water)
Dizziness
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased
Chest pain
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

60+:

Death
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Thromboembolism (obstruction of artery by blood clot)
Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug maladministration
Hyperkalaemia (damage to or disease of the kidney)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 24.14%
Antiphospholipid Syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss): 7 people, 24.14%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 5 people, 17.24%
Shrinking Lung Syndrome (decrease lung capacity due to lupus (a collection of autoimmune diseases)): 5 people, 17.24%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 5 people, 17.24%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 10.34%
Renal Cell Carcinoma (a kidney cancer): 2 people, 6.90%
Nausea (feeling of having an urge to vomit): 2 people, 6.90%
Malignant Urinary Tract Neoplasm (cancer tumour of urinary tract organs): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and Innohep?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously