Benadryl and Kanuma drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Kanuma (sebelipase alfa). Common drug interactions include infectious mononucleosis among females and urticaria among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Kanuma. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Kanuma?

Kanuma has active ingredients of sebelipase alfa. eHealthMe is studying from 605 Kanuma users. Check the latest studies of Kanuma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

14 people who take Benadryl and Kanuma together, and have interactions are studied.

What are the common drug interactions of Benadryl and Kanuma, by gender? *:

female:

Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Infusion related reaction
Pleural effusion (water on the lungs)
Pyrexia (fever)
Septic shock (shock due to blood infection)

male:

Urticaria (rash of round, red welts on the skin that itch intensely)
Diarrhoea
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Total cholesterol/hdl ratio increased
Abdominal discomfort
Abdominal pain
Abdominal pain upper
Anxiety
Blood cholesterol increased

What are the common drug interactions of Benadryl and Kanuma, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Diarrhoea
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Diarrhoea haemorrhagic (bloody diarrhoea)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Septic shock (shock due to blood infection)
Tooth abscess (pus formation in tooth)
Abdominal pain upper

10-19:

Infectious mononucleosis (infection usually caused by the epstein-barr virus)

20-29:

Infusion related reaction
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Adverse reaction
Fatigue (feeling of tiredness)
Sinusitis (inflammation of sinus)
Urticaria (rash of round, red welts on the skin that itch intensely)
Anaphylactic reaction (serious allergic reaction)
Chest discomfort
Drug hypersensitivity

30-39:

Abdominal discomfort
Abdominal pain
Diarrhoea
Lethargy (tiredness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Hypersensitivity: 3 people, 21.43%
Pain: 3 people, 21.43%
Infection: 3 people, 21.43%
Sedation: 3 people, 21.43%
Nausea (feeling of having an urge to vomit): 3 people, 21.43%
Nausea And Vomiting: 3 people, 21.43%
Laxative Supportive Care: 2 people, 14.29%
Fever: 2 people, 14.29%
Muscle Spasms (muscle contraction): 2 people, 14.29%
Indigestion: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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