Benadryl and Lenvatinib drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Lenvatinib (lenvatinib). Common drug interactions include hypertransaminasaemia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Lenvatinib. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Lenvatinib?

Lenvatinib has active ingredients of lenvatinib. eHealthMe is studying from 3,587 Lenvatinib users. Check the latest studies of Lenvatinib.

eHealtheMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 13, 2026

15 people who take Benadryl and Lenvatinib together, and have interactions are studied.

Benadryl and Lenvatinib drug interactions.

What are the common drug interactions of Benadryl and Lenvatinib, by gender? *:

female:

Hypertransaminasaemia
Nausea (feeling of having an urge to vomit)
Hypertension (high blood pressure)
Infusion related reaction
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Nephrolithiasis (calculi in the kidneys)

male:

Diarrhoea
Hypoxia (low oxygen in tissues)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypertension (high blood pressure)
Soft tissue infection

What are the common drug interactions of Benadryl and Lenvatinib, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Nephrolithiasis (calculi in the kidneys)
Diarrhoea
Hypertension (high blood pressure)
Hypoxia (low oxygen in tissues)
Infusion related reaction
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

60+:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Hypertension (high blood pressure)
Soft tissue infection
Hypertransaminasaemia
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 6 people, 40.00%
Oesophageal Adenocarcinoma (a cancer tumour of an epithelium in oesophagus): 3 people, 20.00%
Hepatocellular Carcinoma (liver cancer): 1 person, 6.67%
Endometrial Cancer: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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