Benadryl and Lotrimin af drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Lotrimin af (clotrimazole). Common drug interactions include headache among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Lotrimin af. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Lotrimin af?

Lotrimin af has active ingredients of clotrimazole. eHealthMe is studying from 471 Lotrimin af users. Check the latest studies of Lotrimin af.

On Aug, 02, 2026

16 people who take Benadryl and Lotrimin af together, and have interactions are studied.

Benadryl and Lotrimin af drug interactions.

What are the common drug interactions of Benadryl and Lotrimin Af, by gender? *:

female:

Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Balance disorder
Dizziness
Somnolence (a state of near-sleep, a strong desire for sleep)
Apathy
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood pressure increased
Erythema (redness of the skin)
Face oedema (swelling of face)

male:

Drug hypersensitivity
Gingivitis (inflammation of gums)
Skin exfoliation (removal of the oldest dead skin cells)
Streptococcal infection
Dyspnoea exertional (breathlessness or shortness of breath)
Pulmonary valve incompetence
Haemoglobin decreased
Heparin-induced thrombocytopenia
Rash
Red blood cell count decreased

What are the common drug interactions of Benadryl and Lotrimin Af, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dyspnoea exertional (breathlessness or shortness of breath)
Pulmonary valve incompetence

20-29:

n/a

30-39:

n/a

40-49:

Balance disorder
Dizziness
Headache (pain in head)
Somnolence (a state of near-sleep, a strong desire for sleep)
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Suicide attempt

60+:

Drug hypersensitivity
Gingivitis (inflammation of gums)
Face oedema (swelling of face)
Feeling hot
Headache (pain in head)
Heart valve incompetence (heart's valves do not work correctly)
Hypotension (abnormally low blood pressure)
Irritability
Lower respiratory tract infection
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 4 people, 25.00%
Nausea (feeling of having an urge to vomit): 4 people, 25.00%
Itching: 3 people, 18.75%
Rashes (redness): 3 people, 18.75%
Constipation: 3 people, 18.75%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 12.50%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 2 people, 12.50%
Chest Pain: 2 people, 12.50%
Dyspnea (difficult or laboured breathing): 2 people, 12.50%
Hypersensitivity: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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