Benadryl and Methylfolate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Methylfolate (folic acid). Common drug interactions include migraine among females and rash among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Methylfolate. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,018 Methylfolate users. Check the latest studies of Methylfolate.

On Jul, 14, 2026

23 people who take Benadryl and Methylfolate together, and have interactions are studied.

Benadryl and Methylfolate drug interactions.

What are the common drug interactions of Benadryl and Methylfolate, by gender? *:

female:

Migraine (headache)
Fungal infection
Nausea (feeling of having an urge to vomit)
Anxiety
Dizziness
Sinusitis (inflammation of sinus)
Arthralgia (joint pain)
Chest pain
Drug intolerance (drug sensitivity)
Epistaxis (bleed from the nose)

male:

Rash
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Peroneal nerve palsy
Phantom pain
Pneumonia
Sunburn
Dehydration (dryness resulting from the removal of water)
Dizziness
Haemoglobin decreased

What are the common drug interactions of Benadryl and Methylfolate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chest pain
Electrocardiogram qt prolonged
Haemorrhage (bleeding)
Herpes zoster
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
Syncope (loss of consciousness with an inability to maintain postural tone)
Uterine pain
Vomiting

30-39:

Diarrhoea
Dyspepsia (indigestion)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Vomiting

40-49:

Anaphylactic reaction (serious allergic reaction)
Application site burn
Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest discomfort
Chest pain
Contrast media reaction (reaction associated with the use of intravenous contrast material during radiology)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

50-59:

Headache (pain in head)

60+:

Rash
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Peroneal nerve palsy
Phantom pain
Pneumonia
Sunburn
Dehydration (dryness resulting from the removal of water)
Dizziness
Haemoglobin decreased
Hallucination (an experience involving the perception of something not present)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 7 people, 30.43%
Migraine (headache): 6 people, 26.09%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 17.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 17.39%
Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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