Benadryl and Minitran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Minitran (nitroglycerin). Common drug interactions include chest wall mass among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Minitran. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Minitran?

Minitran has active ingredients of nitroglycerin. eHealthMe is studying from 950 Minitran users. Check the latest studies of Minitran.

On Jul, 30, 2026

12 people who take Benadryl and Minitran together, and have interactions are studied.

Benadryl and Minitran drug interactions.

What are the common drug interactions of Benadryl and Minitran, by gender? *:

female:

Chest wall mass
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Coronary artery stenosis (narrowing of coronary artery)
Cough
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dermal cyst
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

male:

Pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Disturbance in attention
Dry mouth
Headache (pain in head)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypoaesthesia (reduced sense of touch or sensation)
Lymphoma (cancer that begins in immune system cells)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to spine (cancer spreads to spine)

What are the common drug interactions of Benadryl and Minitran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Asthma
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cardiomyopathy (weakening of the heart muscle)
Chest pain
Costochondritis (chest wall pain)
Depression
Dyspareunia (painful sexual intercourse)
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)
Fibromyalgia (a long-term condition which causes pain all over the body)

60+:

Fall
Abdominal pain
Blood pressure increased
Blood urea increased
Bone pain
Brain neoplasm (tumour of brain)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac murmur (an heart sound in valve abnormality)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)

What are the existing conditions these people have? *

Chest Pain: 3 people, 25.00%
Gastric Disorder (disease of stomach): 2 people, 16.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 16.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 16.67%
Hypersensitivity: 2 people, 16.67%
High Blood Pressure: 2 people, 16.67%
High Blood Cholesterol: 2 people, 16.67%
Sleep Disorder: 2 people, 16.67%
Arrhythmias (irregular heartbeat): 1 person, 8.33%
Bladder Disorder: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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