Benadryl and Nicorette drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Nicorette (nicotine polacrilex). Common drug interactions include somnolence among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Nicorette. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Nicorette?

Nicorette has active ingredients of nicotine polacrilex. It is often used in quit smoking. eHealthMe is studying from 18,484 Nicorette users. Check the latest studies of Nicorette.

On Jul, 07, 2026

34 people who take Benadryl and Nicorette together, and have interactions are studied.

Benadryl and Nicorette drug interactions.

What are the common drug interactions of Benadryl and Nicorette, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Therapeutic response decreased (less preventive response)
Wound
Asthenia (weakness)
Pain
Oral discomfort (pain or irritation in mouth)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Dizziness
Dry skin
Fatigue (feeling of tiredness)

male:

Chronic kidney disease
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Urinary tract infection
Abdominal compartment syndrome (increased pressure in abdomen)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bacterial infection
Constipation
Gastric ulcer (stomach ulcer)
Haemodynamic instability (disturbances in the blood movement in our body)
Hepatic failure (liver failure)

What are the common drug interactions of Benadryl and Nicorette, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Renal failure (kidney dysfunction)
Abdominal compartment syndrome (increased pressure in abdomen)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bacterial infection
Gastric ulcer (stomach ulcer)
Haemodynamic instability (disturbances in the blood movement in our body)
Hepatic failure (liver failure)
Klebsiella bacteraemia (klebsiella bacteria in blood after infection to lungs)
Lactic acidosis (low ph in body tissues)

30-39:

Chronic kidney disease
Gait disturbance
Lower respiratory tract infection
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Renal failure (kidney dysfunction)

40-49:

Skin disorder (skin disease)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Thermal burn (burn by heat)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Completed suicide (act of taking one's own life)
Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Dysstasia (difficulty in standing)

50-59:

Staphylococcal infection (an infection with staphylococcus bacteria)
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Chronic kidney disease
Constipation
Dehydration (dryness resulting from the removal of water)
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Hypertension (high blood pressure)
Jaundice cholestatic
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Nephrolithiasis (calculi in the kidneys)

60+:

Blood creatinine increased
Hypotension (abnormally low blood pressure)
Dyspnoea (difficult or laboured respiration)
Mania (a state of abnormally elevated or irritable mood)
Nausea (feeling of having an urge to vomit)
Oral pain
Pneumonia
Asthenia (weakness)
Cellulitis (infection under the skin)
Chest pain

What are the existing conditions these people have? *

Insomnia (sleeplessness): 6 people, 17.65%
High Blood Pressure: 6 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 14.71%
Multiple Allergies (allergy to multiple agents): 5 people, 14.71%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 11.76%
Blood Pressure Abnormal: 4 people, 11.76%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 4 people, 11.76%
Gastric Ulcer (stomach ulcer): 4 people, 11.76%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 11.76%
Pain: 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

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