Benadryl and Para drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Para (para - aminobenzoic acid (paba)). Common drug interactions include drug ineffective among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Para. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,956 Benadryl users. Check the latest studies of Benadryl.

What is Para?

Para has active ingredients of para - aminobenzoic acid (paba). eHealthMe is studying from 2,194 Para users. Check the latest studies of Para.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

11 people who take Benadryl and Para together, and have interactions are studied.

What are the common drug interactions of Benadryl and Para, by gender? *:

female:

Drug ineffective
Malaise (a feeling of general discomfort or uneasiness)
Weight decreased
Urticaria (rash of round, red welts on the skin that itch intensely)
Colitis ulcerative (inflammation of colon with ulcer)
Haematochezia (passage of stools containing blood)
Pain in extremity
Pyrexia (fever)
Rectal haemorrhage (bleeding from anus)
Weight increased

male:

Anxiety
Arthralgia (joint pain)
Heart rate increased
Pain in extremity
Skin disorder (skin disease)
Weight increased
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Hypertension (high blood pressure)
Abscess (pus)
Dizziness

What are the common drug interactions of Benadryl and Para, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anal fissure
Anxiety
Asthenia (weakness)
Diarrhoea
Erythema (redness of the skin)
Haemorrhage (bleeding)
Malaise (a feeling of general discomfort or uneasiness)
Nervousness
Rash erythematous (redness of the skin)
Rectal haemorrhage (bleeding from anus)

30-39:

Colitis ulcerative (inflammation of colon with ulcer)
Haematochezia (passage of stools containing blood)
Malaise (a feeling of general discomfort or uneasiness)
Pain in extremity
Pyrexia (fever)
Weight decreased
Body temperature decreased
Body temperature fluctuation
Chest discomfort
Decreased appetite

40-49:

Arthralgia (joint pain)
Drug level above therapeutic
Heart rate increased
Pain in extremity
Skin disorder (skin disease)
Weight increased
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Hypertension (high blood pressure)
Abscess (pus)
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 63.64%
Pain: 4 people, 36.36%
Hypersensitivity: 4 people, 36.36%
Headache (pain in head): 4 people, 36.36%
Gastrointestinal Pain: 4 people, 36.36%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 27.27%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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