Benadryl and Peg-intron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Peg-intron (peginterferon alfa-2b). Common drug interactions include white blood cell count decreased among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Peg-intron. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Peg-intron?

Peg-intron has active ingredients of peginterferon alfa-2b. eHealthMe is studying from 11,142 Peg-intron users. Check the latest studies of Peg-intron.

On Jul, 10, 2026

60 people who take Benadryl and Peg-intron together, and have interactions are studied.

Benadryl and Peg-intron drug interactions.

What are the common drug interactions of Benadryl and Peg-Intron, by gender? *:

female:

White blood cell count decreased
Depression
Haematemesis (vomiting of blood)
Irritability
Faeces discoloured
Headache (pain in head)
Alopecia (absence of hair from areas of the body)
Anger
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

male:

Depression
Fatigue (feeling of tiredness)
Sinusitis (inflammation of sinus)
Suicide attempt
Abscess jaw (tooth abscess or root abscess)
Adnexa uteri mass (ovarian cysts)
Anaemia (lack of blood)
Angioedema (rapid swelling of the dermis)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)

What are the common drug interactions of Benadryl and Peg-Intron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Depression
Suicide attempt
Panic attack
Panic reaction

30-39:

Activated partial thromboplastin time prolonged
Anger
Aplasia pure red cell (type of anaemia affecting the precursors to red blood cells but not to white blood cells)
Asthenia (weakness)
Depression
Faeces discoloured
Fatigue (feeling of tiredness)
Haematemesis (vomiting of blood)
Hepatic failure (liver failure)
Klebsiella sepsis (klebsiella causes a potentially fatal whole-body inflammation)

40-49:

Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
White blood cell count decreased
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood insulin increased

50-59:

Arthralgia (joint pain)
Carotid artery stenosis (narrowing of carotid artery)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dehydration (dryness resulting from the removal of water)
Dental caries
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

60+:

Anxiety
Abscess jaw (tooth abscess or root abscess)
Cataract (clouding of the lens inside the eye)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Coital bleeding (bleeding after sexual intercourse)
Conjunctivitis bacterial (infection of conjunctiva by bacteria)
Conjunctivitis viral (infection of conjunctiva by virus)
Corneal abrasion (loss of the surface of cornea)
Decreased interest
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the existing conditions these people have? *

Hepatitis C: 46 people, 76.67%

* Approximation only. Some reports may have incomplete information.

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