Benadryl and Prevpac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Prevpac (amoxicillin; clarithromycin; lansoprazole). Common drug interactions include chronic kidney disease among females.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Prevpac. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Prevpac?

Prevpac has active ingredients of amoxicillin; clarithromycin; lansoprazole. It is often used in helicobacter pylori. eHealthMe is studying from 758 Prevpac users. Check the latest studies of Prevpac.

On Jul, 15, 2026

14 people who take Benadryl and Prevpac together, and have interactions are studied.

What are the common drug interactions of Benadryl and Prevpac, by gender? *:

female:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Microcytic anaemia (a generic term for any type of anaemia characterized by small red blood cells)
Nephropathy (damage to or disease of a kidney)
Peritoneal adhesions

male:

n/a

What are the common drug interactions of Benadryl and Prevpac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Renal failure (kidney dysfunction)
Appendicitis (inflammation of the appendix)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Microcytic anaemia (a generic term for any type of anaemia characterized by small red blood cells)
Peritoneal adhesions
Spinal osteoarthritis (joint cartilage loss in spine)
Tonsillar hypertrophy (enlargement of the tonsils)
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

n/a

50-59:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Nephropathy (damage to or disease of a kidney)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

Chronic kidney disease

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 92.86%
High Blood Pressure: 9 people, 64.29%
Pain: 8 people, 57.14%
High Blood Cholesterol: 6 people, 42.86%
Hypersensitivity: 6 people, 42.86%
Cardiac Disorder: 5 people, 35.71%
Stress And Anxiety: 5 people, 35.71%
Bone Disorder: 4 people, 28.57%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 21.43%
Gastric Ulcer (stomach ulcer): 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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