Benadryl and Qulipta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Qulipta (atogepant). Common drug interactions include headache among females and bowel movement irregularity among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Qulipta. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Qulipta?

Qulipta has active ingredients of atogepant. eHealthMe is studying from 3,605 Qulipta users. Check the latest studies of Qulipta.

On Aug, 09, 2026

36 people who take Benadryl and Qulipta together, and have interactions are studied.

What are the common drug interactions of Benadryl and Qulipta, by gender? *:

female:

Headache (pain in head)
Respiratory tract infection
Sinus disorder (disease of sinus)
Urinary tract infection
Nausea (feeling of having an urge to vomit)
Adverse event
Anxiety
Blood pressure fluctuation
Cardiac failure
Coronavirus test positive

male:

Bowel movement irregularity
Constipation
Malignant glioma (cancerous tumour of brain a cancer tumour of uncertain origin that arises both in soft tissue and bone)
Migraine (headache)
Swelling
Swollen tongue (swelling of tongue)
Vomiting

What are the common drug interactions of Benadryl and Qulipta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)
Heart rate increased
Infusion related reaction
Injection site discolouration
Injection site pain
Injection site rash
Malignant glioma (cancerous tumour of brain a cancer tumour of uncertain origin that arises both in soft tissue and bone)
Palpitations (feelings or sensations that your heart is pounding or racing)
Rash pruritic (redness with itching)
Urticaria (rash of round, red welts on the skin that itch intensely)

30-39:

Agitation (state of anxiety or nervous excitement)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Depression
Genital herpes (herpes infection of genital)
Memory impairment
Pyrexia (fever)
Rash erythematous (redness of the skin)
Rash papular (redness with papule)

40-49:

Adverse event
Dyspepsia (indigestion)
Headache (pain in head)
Lip swelling
Swelling face
Throat irritation
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Abdominal pain upper
Sinusitis (inflammation of sinus)
Respiratory tract infection
Nausea (feeling of having an urge to vomit)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nasopharyngitis (inflammation of the nasopharynx)
Vomiting
Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Dyspepsia (indigestion)
Infusion site extravasation (flow of (blood or lymph) from infusion site)

60+:

Coronavirus test positive
Decreased appetite
Infection
Infusion site pain
Lymphoma (cancer that begins in immune system cells)
Malaise (a feeling of general discomfort or uneasiness)
Mass
Oral infection
Oral pain
Oral viral infection

What are the existing conditions these people have? *

Migraine (headache): 14 people, 38.89%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 5 people, 13.89%
Supraventricular Extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle): 2 people, 5.56%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 5.56%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.56%
Pain: 2 people, 5.56%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 2 people, 5.56%
Immunodeficiency Common Variable: 2 people, 5.56%
Hypersensitivity: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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