Benadryl and Renflexis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Renflexis (infliximab-abda). Common drug interactions include neuralgia among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Renflexis. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

What is Renflexis?

Renflexis has active ingredients of infliximab-abda. eHealthMe is studying from 1,316 Renflexis users. Check the latest studies of Renflexis.

On Aug, 12, 2026

49 people who take Benadryl and Renflexis together, and have interactions are studied.

Benadryl and Renflexis drug interactions.

What are the common drug interactions of Benadryl and Renflexis, by gender? *:

female:

Neuralgia (pain in one or more nerves)
Presyncope
Psoriasis (immune-mediated disease that affects the skin)
Restlessness (not able to rest)
Stress
Agitation (state of anxiety or nervous excitement)
Bacterial infection
Blood pressure decreased
Body temperature increased
Cough

male:

Back pain
Chest discomfort
Fatigue (feeling of tiredness)
Feeling hot
Urticaria (rash of round, red welts on the skin that itch intensely)
Body temperature increased
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain

What are the common drug interactions of Benadryl and Renflexis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Fatigue (feeling of tiredness)
Bacterial infection
Body temperature increased
Drug level decreased
Infusion related reaction
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
Infusion site rash
Joint stiffness
Malaise (a feeling of general discomfort or uneasiness)

20-29:

Dyspnoea (difficult or laboured respiration)
Feeling hot
Headache (pain in head)
Heart rate increased
Vomiting
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Somnolence (a state of near-sleep, a strong desire for sleep)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)

30-39:

Somnolence (a state of near-sleep, a strong desire for sleep)
Colitis ulcerative (inflammation of colon with ulcer)
Maternal exposure during pregnancy (use of substance during pregnancy)
Palpitations (feelings or sensations that your heart is pounding or racing)
Blood pressure systolic increased
Burning sensation
Chest discomfort
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Epigastric discomfort
Erythema (redness of the skin)

40-49:

Vomiting
Abdominal discomfort
Abdominal pain upper
Ankylosing spondylitis (type of arthritis affecting the spine)
Aphonia (inability to produce voice)
Asthenia (weakness)
Asthma
Back pain
Cardiac disorder
Chest discomfort

50-59:

Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Nausea (feeling of having an urge to vomit)
Apnoea (suspension of external breathing)
Chest discomfort
Fatigue (feeling of tiredness)
Loss of consciousness
Perfume sensitivity
Speech disorder

60+:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal pain
Discomfort
Muscle spasms (muscle contraction)
Weight increased
Colitis ulcerative (inflammation of colon with ulcer)
Drug specific antibody present
Dyspnoea (difficult or laboured respiration)
Heart rate increased
Anxiety

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 17 people, 34.69%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 16 people, 32.65%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 12.24%
Pain: 3 people, 6.12%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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