Benadryl and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Sinemet (carbidopa; levodopa). Common drug interactions include pain in extremity among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Sinemet. It is created by eHealthMe based on reports of 200 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.



On Jul, 06, 2026

200 people who take Benadryl and Sinemet together, and have interactions are studied.

Benadryl and Sinemet drug interactions.

What are the common drug interactions of Benadryl and Sinemet, by gender? *

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What are the common drug interactions of Benadryl and Sinemet, by age (0-1 to 60+)? *

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What are the existing conditions these people have? *

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* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and Sinemet?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Benadryl and Sinemet:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Benadryl:

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Browse all side effects of Sinemet:

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Browse all interactions between Benadryl and drugs from A to Z:

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Browse all interactions between Sinemet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride and carbidopa; levodopa (the active ingredients of Benadryl and Sinemet, respectively), and Benadryl and Sinemet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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