Benadryl and Stadol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Stadol (butorphanol tartrate). Common drug interactions include mental disorder among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Stadol. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Stadol?

Stadol has active ingredients of butorphanol tartrate. It is often used in migraine. eHealthMe is studying from 5,546 Stadol users. Check the latest studies of Stadol.

On Jul, 18, 2026

41 people who take Benadryl and Stadol together, and have interactions are studied.

What are the common drug interactions of Benadryl and Stadol, by gender? *:

female:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mitral valve incompetence (inefficient heart valve)
Obesity (having too much body fat)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pyrexia (fever)
Stress
Tremor (trembling or shaking movements in one or more parts of your body)
Adverse drug reaction
Confusional state
Drug intolerance (drug sensitivity)

male:

Dizziness
Dependence
Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)
Death
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Diplopia (double vision)
Drug administration error
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

What are the common drug interactions of Benadryl and Stadol, by age (0-1 to 60+)? *:

0-1:

Asthenia (weakness)
Back pain
Diplopia (double vision)
Dizziness
Eyelid ptosis (falling of the upper or lower eyelid)
Fall
Gait disturbance
Headache (pain in head)
Impaired driving ability
Injection site reaction

2-9:

n/a

10-19:

Death
Dependence

20-29:

Adjustment disorder
Aggression
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Depressed mood
Drug abuser
Drug addiction
Drug dependence
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Psychomotor retardation (motor mental retardation)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)

30-39:

Abdominal pain
Gastritis (inflammation of stomach)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Depression
Dizziness
Enteritis (inflammation of the small intestine)
Gallbladder disorder
Headache (pain in head)
Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)

40-49:

Arthralgia (joint pain)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Overdose
Vomiting
Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Arrhythmia (irregular heartbeat)
Back pain
Blood parathyroid hormone increased

50-59:

Cardiac murmur (an heart sound in valve abnormality)
Cardiac valve disease (heart valve disease)
Cardiomegaly (increased size of heart than normal)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Coronary artery stenosis (narrowing of coronary artery)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)

60+:

Agitation (state of anxiety or nervous excitement)
Alanine aminotransferase increased
Blood glucose increased
Blood potassium decreased
Blood urea increased
Confusional state
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Granulocyte count increased
Haemorrhage intracranial (bleeding within the skull)

What are the existing conditions these people have? *

Pain: 6 people, 14.63%
Nausea (feeling of having an urge to vomit): 4 people, 9.76%
High Blood Pressure: 4 people, 9.76%
Depression: 4 people, 9.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 7.32%
Insomnia (sleeplessness): 3 people, 7.32%
Hypersensitivity: 3 people, 7.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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