Benadryl and Ticagrelor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benadryl (diphenhydramine hydrochloride) and Ticagrelor (ticagrelor). Common drug interactions include arthralgia among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Benadryl and Ticagrelor. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Ticagrelor?

Ticagrelor has active ingredients of ticagrelor. eHealthMe is studying from 8,499 Ticagrelor users. Check the latest studies of Ticagrelor.

On Jul, 11, 2026

32 people who take Benadryl and Ticagrelor together, and have interactions are studied.

Benadryl and Ticagrelor drug interactions.

What are the common drug interactions of Benadryl and Ticagrelor, by gender? *:

female:

Arthralgia (joint pain)
Clumsiness (a lack of coordination or elegance)
Cough
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Dry mouth
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Headache (pain in head)
Influenza

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Heart rate decreased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood urine present
Drug hypersensitivity
Fluid retention (an abnormal accumulation of fluid in the blood)
Heart rate increased
Hypotension (abnormally low blood pressure)
Blood pressure systolic increased
Bradycardia (abnormally slow heart action)

What are the common drug interactions of Benadryl and Ticagrelor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arthralgia (joint pain)
Clumsiness (a lack of coordination or elegance)
Cough
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Dry mouth
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Headache (pain in head)
Influenza

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Heart rate decreased
Hypotension (abnormally low blood pressure)
Viral infection
Basal ganglia infarction (disruption of the blood flow in the small blood vessels in the white matter of the cerebral cortex)
Blood pressure systolic increased
Bradycardia (abnormally slow heart action)
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 24 people, 75.00%
Chest Pain: 3 people, 9.38%
Pain: 2 people, 6.25%
Indigestion: 2 people, 6.25%
Heart Attack: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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