Benzonatate and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include gastrooesophageal reflux disease among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Macrobid. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Aug, 01, 2026

65 people who take Benzonatate and Macrobid together, and have interactions are studied.

Benzonatate and Macrobid drug interactions.

What are the common drug interactions of Benzonatate and Macrobid, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Impulsive behaviour
Mania (a state of abnormally elevated or irritable mood)
Neuropathy peripheral (surface nerve damage)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Osteomyelitis (infection of bone)
Osteonecrosis (death of bone)
Periodontitis (inflammation of the tissue around the teeth)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)

male:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Abdominal pain
Abnormal faeces (abnormal stool)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Adenocarcinoma pancreas (cancer of pancreas)
Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Anaemia megaloblastic (disorder of abnormally large red blood cells)
Angina pectoris (chest pain due to ischemia of the heart muscle)

What are the common drug interactions of Benzonatate and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anion gap decreased
Bankruptcy
Blood calcium decreased
Blood chloride increased
Blood creatine phosphokinase increased
Blood urea decreased
Carbon dioxide increased
Haematocrit decreased
Haemoglobin decreased
Impulsive behaviour

30-39:

Anxiety
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Fibromyalgia (a long-term condition which causes pain all over the body)
Mania (a state of abnormally elevated or irritable mood)
Neuropathy peripheral (surface nerve damage)
Renal failure (kidney dysfunction)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Chronic kidney disease

40-49:

Renal failure (kidney dysfunction)
Adenocarcinoma pancreas (cancer of pancreas)
Agitation (state of anxiety or nervous excitement)
Alanine aminotransferase increased
Asthenia (weakness)
Blood alkaline phosphatase increased
Blood glucose increased
Blood urea increased
Blood urea nitrogen/creatinine ratio increased
Chronic kidney disease

50-59:

Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lung neoplasm (tumour of lung)
Neck pain
Oesophageal disorder (disease of oesophagus)
Proteinuria (presence of protein in the urine)
Renal failure chronic (long lasting kidney dysfunction)
Systemic sclerosis (an autoimmune or connective tissue disease. it is characterized by thickening of the skin)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abscess (pus)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Dyspnoea (difficult or laboured respiration)
Hypermetropia (abnormal condition in which vision for distant objects is better than for near objects)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Nephrogenic anaemia (anaemia due to kidney disease)
Oedema peripheral (superficial swelling)
Pain
Pain in extremity
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 25 people, 38.46%
High Blood Pressure: 22 people, 33.85%
Pain: 19 people, 29.23%
Stress And Anxiety: 18 people, 27.69%
Depression: 16 people, 24.62%
Infection: 11 people, 16.92%
Insomnia (sleeplessness): 9 people, 13.85%
Muscle Spasms (muscle contraction): 9 people, 13.85%
Neuralgia (pain in one or more nerves): 8 people, 12.31%
Rickets (softening of bones): 8 people, 12.31%

* Approximation only. Some reports may have incomplete information.

Do you take Benzonatate and Macrobid?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously