Benzonatate and Serevent drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Serevent (salmeterol xinafoate). Common drug interactions include arthritis bacterial among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Serevent. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Serevent?

Serevent has active ingredients of salmeterol xinafoate. It is often used in asthma. eHealthMe is studying from 15,586 Serevent users. Check the latest studies of Serevent.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

58 people who take Benzonatate and Serevent together, and have interactions are studied.

Benzonatate and Serevent drug interactions.

What are the common drug interactions of Benzonatate and Serevent, by gender? *:

female:

Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Arthropathy
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Bacterial diarrhoea
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Bullous lung disease
Chest pain
Decreased appetite

male:

Fatigue (feeling of tiredness)
Diarrhoea
Abasia (inability to walk)
Abscess limb (limb infection)
Adjustment disorder
Affect lability (emotional incontinence)
Alcoholism (problems with alcohol)
Anxiety
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Benzonatate and Serevent, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abasia (inability to walk)
Arthralgia (joint pain)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Femur fracture
Pain in extremity
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Cardiac disorder

10-19:

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

20-29:

n/a

30-39:

Drug hypersensitivity
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Renal impairment (severely reduced kidney function)
Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

Agitation (state of anxiety or nervous excitement)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Axillary pain
Chronic obstructive airways disease
Drug addiction
Drug tolerance increased
Erectile dysfunction
Fall
General physical health deterioration (weak health status)

50-59:

Headache (pain in head)
Fatigue (feeling of tiredness)
Back pain
Dyspnoea (difficult or laboured respiration)
Impaired work ability
Implant infection (infection at implant site)
Oxygen saturation decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
Septicaemia staphylococcal (blood infection with bacteria)
Surgery

60+:

Dyspnoea (difficult or laboured respiration)
Chronic kidney disease
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pruritus (severe itching at infusion site)
Infusion site swelling
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Renal failure (kidney dysfunction)
Allergic respiratory disease
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 22.41%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 11 people, 18.97%
High Blood Pressure: 9 people, 15.52%
Hypersensitivity: 9 people, 15.52%
Diabetes: 8 people, 13.79%
Infection: 8 people, 13.79%
Immunodeficiency Common Variable: 7 people, 12.07%
Rashes (redness): 7 people, 12.07%
Multiple Allergies (allergy to multiple agents): 7 people, 12.07%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 12.07%

* Approximation only. Some reports may have incomplete information.

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