Benzonatate and Silvadene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Benzonatate (benzonatate) and Silvadene (silver sulfadiazine). Common drug interactions include irritable bowel syndrome among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Benzonatate and Silvadene. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Silvadene?

Silvadene has active ingredients of silver sulfadiazine. eHealthMe is studying from 1,161 Silvadene users. Check the latest studies of Silvadene.

On Jul, 12, 2026

21 people who take Benzonatate and Silvadene together, and have interactions are studied.

Benzonatate and Silvadene drug interactions.

What are the common drug interactions of Benzonatate and Silvadene, by gender? *:

female:

Irritable bowel syndrome
Joint crepitation
Klebsiella infection
Klebsiella test positive
Lethargy (tiredness)
Liver disorder (liver diseases)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain

male:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Pain
Pertussis (whooping cough: a disease of the respiratory mucous membrane)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Stress
Tooth loss
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Anxiety

What are the common drug interactions of Benzonatate and Silvadene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Pertussis (whooping cough: a disease of the respiratory mucous membrane)

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Pain
Blood hiv rna increased
Chronic kidney disease
Osteoporosis (bones weak and more likely to break)
Osteoporotic fracture (fracture due to weak bone)
Synovial cyst (cyst of joint filled with synovial fluid)

50-59:

Abdominal hernia
Abdominal pain lower
Arthralgia (joint pain)
Back pain
Body temperature increased
Bone pain
Breast cellulitis (spreading, acute inflammation of beast skin)
Breast pain
Chest discomfort
Chest pain

60+:

Breast cancer
Hypertension (high blood pressure)
Disease progression
Drug hypersensitivity
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Hepatic enzyme increased
Nausea (feeling of having an urge to vomit)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Renal injury (kidney injury)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 7 people, 33.33%
Osteoporosis (bones weak and more likely to break): 4 people, 19.05%
Vitamin B12 Deficiency: 3 people, 14.29%
Urinary Tract Infection: 3 people, 14.29%
Upper Respiratory Tract Infection: 3 people, 14.29%
Sinusitis (inflammation of sinus): 3 people, 14.29%
Rickets (softening of bones): 3 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 14.29%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 14.29%
Hiv Infection: 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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