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Bepreve and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bepreve (bepotastine besilate) and Provigil (modafinil). Common drug interactions include migraine among females.

The phase IV clinical study analyzes what interactions people have when they take Bepreve and Provigil. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Bepreve?

Bepreve has active ingredients of bepotastine besilate. eHealthMe is studying from 527 Bepreve users. Check the latest studies of Bepreve.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

On Jul, 26, 2026

11 people who take Bepreve and Provigil together, and have interactions are studied.

Bepreve and Provigil drug interactions.

What are the common drug interactions of Bepreve and Provigil, by gender? *:

female:

  1. Migraine (headache)
  2. Anxiety
  3. Influenza like illness
  4. Injection site haemorrhage (bleeding from injection site)
  5. Myalgia (muscle pain)
  6. Pruritus (severe itching of the skin)
  7. Suicidal ideation
  8. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  9. Throat tightness
  10. Urticaria (rash of round, red welts on the skin that itch intensely)

male:

n/a

What are the common drug interactions of Bepreve and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Chest discomfort
  2. Dysphagia (a condition in which swallowing is difficult or painful)
  3. Pruritus (severe itching of the skin)
  4. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  5. Throat tightness

30-39:

n/a

40-49:

  1. Arthralgia (joint pain)
  2. Influenza like illness
  3. Myalgia (muscle pain)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 63.64%
  2. Urticaria Chronic (long lasting rash of round, red welts on the skin that itch intensely): 1 person, 9.09%
  3. Pain: 1 person, 9.09%
  4. Oedema (fluid collection in tissue): 1 person, 9.09%
  5. Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 1 person, 9.09%
  6. Multiple Allergies (allergy to multiple agents): 1 person, 9.09%
  7. Migraine (headache): 1 person, 9.09%
  8. Idiopathic Urticaria (allergic reactions, presence of hives with unknown cause): 1 person, 9.09%
  9. Hypersensitivity: 1 person, 9.09%
  10. High Blood Pressure: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Bepreve and Provigil?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Bepreve and Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Bepreve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Bepreve and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Provigil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on bepotastine besilate and modafinil (the active ingredients of Bepreve and Provigil, respectively), and Bepreve and Provigil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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