Bextra and Lopid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bextra (valdecoxib) and Lopid (gemfibrozil). Common drug interactions include stevens-johnson syndrome among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Bextra and Lopid. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

What is Lopid?

Lopid has active ingredients of gemfibrozil. It is often used in high blood cholesterol. eHealthMe is studying from 9,700 Lopid users. Check the latest studies of Lopid.

On Jul, 08, 2026

34 people who take Bextra and Lopid together, and have interactions are studied.

What are the common drug interactions of Bextra and Lopid, by gender? *:

female:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Throat tightness
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Ventricular extrasystoles (premature cardiac contraction)
Weight decreased
Abdominal distension
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Acute respiratory failure
Acute right ventricular failure (acute heart attack)

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Anxiety
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anosmia (partial or complete loss of the sense of smell)
Bloody discharge
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough
Drug hypersensitivity

What are the common drug interactions of Bextra and Lopid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Activities of daily living impaired
Arthralgia (joint pain)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Comminuted fracture (bone has broken into several pieces)
Cystitis interstitial (unknown cause characterized by bladder pain)
Fall
Femur fracture
Haemoglobin decreased
Mobility decreased (ability to move is reduced)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

30-39:

Abdominal pain
Affective disorder (mental disorder)
Allergy to arthropod sting
Anxiety disorder
Asthenia (weakness)
Chest pain
Depression
Dizziness
Dysmenorrhoea (painful menstruation)
Dyspepsia (indigestion)

40-49:

Confusional state
Lethargy (tiredness)

50-59:

Loss of consciousness
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nervousness
Oral candidiasis (fungal infection of mouth)
Pancreatic disorder
Pruritus (severe itching of the skin)
Rash
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Scab (a hard coating on the skin formed during the wound healing)

60+:

Abdominal pain upper
Diarrhoea
Drug hypersensitivity
Hypovolaemia (a decreased volume of circulating blood in the body)
Lipase increased
Pancreatitis (inflammation of pancreas)
Renal cyst (kidney cyst)
Renal failure (kidney dysfunction)
Syncope (loss of consciousness with an inability to maintain postural tone)
Urinary tract infection staphylococcal

What are the existing conditions these people have? *

Depression: 7 people, 20.59%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 17.65%
Urinary Tract Infection: 3 people, 8.82%
Osteoporosis (bones weak and more likely to break): 3 people, 8.82%
Muscle Spasms (muscle contraction): 3 people, 8.82%
Hot Flush (sudden feelings of heat): 3 people, 8.82%
High Blood Pressure: 3 people, 8.82%
Dizziness: 3 people, 8.82%
Cough: 3 people, 8.82%
Breast Cancer: 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

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