Yasmin and Melasma - a phase IV clinical study of FDA data

Summary:

Melasma is reported as a side effect among people who take Yasmin (drospirenone; ethinyl estradiol), especially for people who are 30-39 old, have been taking the drug for 2 - 5 years also take Accutane, and have Endometriosis.

The phase IV clinical study analyzes which people have Melasma when taking Yasmin. It is created by eHealthMe based on reports of 47,831 people who have side effects when taking Yasmin from the FDA, and is updated regularly.

What is Yasmin?

Yasmin has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 48,855 Yasmin users. Check the latest studies of Yasmin.

What is Melasma?

Melasma (the mask of pregnancy when present in pregnant women) is a tan or dark skin discoloration) is found to be associated with 40 drugs and 236 conditions by eHealthMe. Check the latest studies of Melasma.

On Jul, 08, 2026

47,831 people reported to have side effects when taking Yasmin.
Among them, 13 people (0.03%) have Melasma.

Among these 13 people:

How long have people been on Yasmin when they have Melasma? *

What is the age of people who have Melasma when taking Yasmin? *

What are other drugs people take besides Yasmin? *

Ortho Tri-Cyclen: 1 person, 7.69%
Mircette: 1 person, 7.69%
Ibuprofen: 1 person, 7.69%
Cytotec: 1 person, 7.69%
Accutane: 1 person, 7.69%

What are other side effects people have besides Melasma? *

Varicose Vein (veins that have become enlarged and tortuous): 6 people, 46.15%
Amenorrhea (absence of a menstrual period in a woman of reproductive age): 6 people, 46.15%
Fatigue (feeling of tiredness): 6 people, 46.15%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 5 people, 38.46%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 38.46%
Angiopathy (generic term for a disease of the blood vessels): 5 people, 38.46%
Chest Pain: 5 people, 38.46%
Discomfort: 5 people, 38.46%
Dizziness: 5 people, 38.46%
Fungal Infection: 5 people, 38.46%

What are the existing conditions these people have? *

Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 2 people, 15.38%
Acne Cystic (skin problems that cause pimples): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Yasmin and have Melasma?

- Check whether Melasma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Yasmin:

Yasmin (48,855 reports)

Melasma treatments and more:

Melasma (1,070 reports)

How severe was Melasma and when was it recovered:

Melasma in Yasmin

Expand to all the drugs that have ingredients of drospirenone; ethinyl estradiol:

Melasma and drugs with ingredients of drospirenone; ethinyl estradiol (22 reports)

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Yasmin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Melasma:

Melasma (40 drugs)

Browse all the conditions that are associated with Melasma:

Melasma (236 conditions)

Related publications that referenced our studies

Locci-Molina N, Wang A, Kroumpouzos G, "Melasma Improving Spontaneously upon Switching from a Combined Oral Contraceptive to a Hormone-releasing Intrauterine Device: A Report of Four Cases", Acta dermato-venereologica, 2015 May .
Locci-Molina N, Wang A, Kroumpouzos G, "Melasma Improving Spontaneously upon Switching from a Combined Oral Contraceptive to a Hormone-releasing Intrauterine Device: A Report of Four Cases", Acta dermato-venereologica, 2015 May .

How the study uses the data?

The study uses data from the FDA. It is based on drospirenone; ethinyl estradiol (the active ingredients of Yasmin) and Yasmin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.