Bextra and Maxalt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bextra (valdecoxib) and Maxalt (rizatriptan benzoate). Common drug interactions include hypothyroidism among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Bextra and Maxalt. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

What is Maxalt?

Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.

On Jul, 07, 2026

22 people who take Bextra and Maxalt together, and have interactions are studied.

What are the common drug interactions of Bextra and Maxalt, by gender? *:

female:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Fall
Femur fracture
Forearm fracture (fracture in between wrist to elbow)
Lower limb fracture
Oesophageal spasm (contraction of oesophagus)
Osteoporosis (bones weak and more likely to break)
Radius fracture
Spinal column stenosis (narrowing of spinal column)
Spinal osteoarthritis (joint cartilage loss in spine)

male:

Emotional distress
Injury
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pathological gambling
Alcohol use
Suicidal ideation
Suicide attempt
Weight decreased

What are the common drug interactions of Bextra and Maxalt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Dyspepsia (indigestion)
Dysthymic disorder (mild chronic depression disorder)
Galactorrhoea (secretion of breast milk in men)
Gallbladder operation
Headache (pain in head)
Hepatitis (inflammation of the liver)

40-49:

Cervix carcinoma (cancer of cervix)
Heart rate increased
Arthropathy
Asthenia (weakness)
Cardiac disorder
Cardiomegaly (increased size of heart than normal)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Depression
Diplegia (paralysis of corresponding parts on both sides of the body)
Disease recurrence

50-59:

Acute respiratory distress syndrome
Acute respiratory failure
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Chronic kidney disease
Coagulopathy (blood's ability to clot is impaired)
Headache (pain in head)
Multi-organ failure (multisystem organ failure)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia

60+:

Depression
Fall
Spinal column stenosis (narrowing of spinal column)
Spinal osteoarthritis (joint cartilage loss in spine)
Tibia fracture (fracture of lower leg bone)
Ulna fracture (fracture inside bone)
Upper limb fracture
Wrist fracture
Vomiting
Headache (pain in head)

What are the existing conditions these people have? *

Depression: 6 people, 27.27%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 22.73%
Vasculitis (inflammation of a blood vessel or blood vessels): 4 people, 18.18%
Irritable Bowel Syndrome: 4 people, 18.18%
High Blood Cholesterol: 4 people, 18.18%
High Blood Pressure: 4 people, 18.18%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 4 people, 18.18%
Allergic Rhinitis: 4 people, 18.18%
Osteoporosis (bones weak and more likely to break): 4 people, 18.18%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 4 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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