Profen and Gengraf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Profen (ibuprofen) and Gengraf (cyclosporine). Common drug interactions include asthenia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Profen and Gengraf. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Gengraf?

Gengraf has active ingredients of cyclosporine. eHealthMe is studying from 960 Gengraf users. Check the latest studies of Gengraf.

On Jul, 07, 2026

14 people who take Profen and Gengraf together, and have interactions are studied.

What are the common drug interactions of Profen and Gengraf, by gender? *:

female:

Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gait disturbance
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Hypoaesthesia (reduced sense of touch or sensation)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Glomerulonephritis membranous (nephritis with inflammation of the capillary loops in the renal glomeruli)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Rash
Nephrogenic anaemia (anaemia due to kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Profen and Gengraf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mesangioproliferative glomerulonephritis (an inflammatory disease of both kidneys)
Nephrogenic anaemia (anaemia due to kidney disease)
Rash
Renal failure (kidney dysfunction)

50-59:

Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory failure (inadequate gas exchange by the respiratory system)
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gait disturbance
Glomerulonephritis membranous (nephritis with inflammation of the capillary loops in the renal glomeruli)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)

60+:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal impairment (severely reduced kidney function)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 57.14%
Indigestion: 7 people, 50.00%
Bone Disorder: 7 people, 50.00%
Cough: 7 people, 50.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 50.00%
High Blood Cholesterol: 6 people, 42.86%
Swelling: 5 people, 35.71%
Chest Pain: 5 people, 35.71%
Hypoparathyroidism (inadequate secretion of parathyroid hormone resulting in abnormally low levels of calcium in the blood): 5 people, 35.71%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 35.71%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and Gengraf?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously