Biktarvy and Creon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Biktarvy (bictegravir sodium; emtricitabine; tenofovir alafenamide fumarate) and Creon (pancrelipase (amylase;lipase;protease)). Common drug interactions include anhedonia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Biktarvy and Creon. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Biktarvy?

Biktarvy has active ingredients of bictegravir sodium; emtricitabine; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 19,543 Biktarvy users. Check the latest studies of Biktarvy.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

On Jul, 08, 2026

18 people who take Biktarvy and Creon together, and have interactions are studied.

What are the common drug interactions of Biktarvy and Creon, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Bone density decreased
Dysstasia (difficulty in standing)
Gait disturbance
Balance disorder

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Nephrolithiasis (calculi in the kidneys)
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Pruritus (severe itching of the skin)
Renal failure (kidney dysfunction)
Tooth loss

What are the common drug interactions of Biktarvy and Creon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Pain
Bone loss
Chronic kidney disease
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Foot fracture

60+:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Pain
Pruritus (severe itching of the skin)
Abdominal pain
Alcohol abuse
Diarrhoea
Gastrointestinal tract adenoma (a benign tumour (-oma) of glandular origin in digestive tract)
Anxiety
Arthralgia (joint pain)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 27.78%
Pain: 4 people, 22.22%
High Blood Pressure: 4 people, 22.22%
Nausea (feeling of having an urge to vomit): 3 people, 16.67%
High Blood Cholesterol: 3 people, 16.67%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 11.11%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 11.11%
Rashes (redness): 2 people, 11.11%
Pancreatic Disorder: 2 people, 11.11%
Hypersensitivity: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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