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Black cohosh and Tecfidera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Black cohosh (black cohosh) and Tecfidera (dimethyl fumarate). Common drug interactions include flushing among females.

The phase IV clinical study analyzes what interactions people have when they take Black cohosh and Tecfidera. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Black cohosh?

Black cohosh has active ingredients of black cohosh. It is often used in menopause. eHealthMe is studying from 1,382 Black cohosh users. Check the latest studies of Black cohosh.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

On Jul, 18, 2026

32 people who take Black cohosh and Tecfidera together, and have interactions are studied.

Black cohosh and Tecfidera drug interactions.

What are the common drug interactions of Black Cohosh and Tecfidera, by gender? *:

female:

  1. Flushing (the warm, red condition of human skin)
  2. Fatigue (feeling of tiredness)
  3. Pain
  4. Weight decreased
  5. Fall
  6. Arterial disorder
  7. Arthralgia (joint pain)
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  9. Bladder disorder
  10. Burning sensation

male:

n/a

What are the common drug interactions of Black Cohosh and Tecfidera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Alopecia (absence of hair from areas of the body)
  2. Flushing (the warm, red condition of human skin)
  3. Gait disturbance
  4. Hepatic enzyme increased
  5. Hypertension (high blood pressure)
  6. Neutropenia (an abnormally low number of neutrophils)
  7. Weight decreased
  8. White blood cell count decreased
  9. Headache (pain in head)

50-59:

  1. Fatigue (feeling of tiredness)
  2. Eye pain
  3. Nausea (feeling of having an urge to vomit)
  4. Actinic keratosis (skin disease due to sun exposure)
  5. Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
  6. Bowen's disease (early stage of skin cancer)
  7. Insomnia (sleeplessness)
  8. Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
  9. Abdominal discomfort
  10. Back pain

60+:

  1. Fall
  2. Fractured sacrum
  3. Chills (felling of cold)
  4. Headache (pain in head)
  5. Hyperhidrosis (abnormally increased sweating)
  6. Irritability
  7. Nausea (feeling of having an urge to vomit)
  8. Pain
  9. Pruritus (severe itching of the skin)
  10. Rash

What are the existing conditions these people have? *

  1. Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 3 people, 9.38%
  2. Gait Disturbance: 3 people, 9.38%
  3. Weakness: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Black cohosh and Tecfidera?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Black cohosh and Tecfidera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Black cohosh:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tecfidera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Black cohosh and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tecfidera and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on black cohosh and dimethyl fumarate (the active ingredients of Black cohosh and Tecfidera, respectively), and Black cohosh and Tecfidera (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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