Brethine and Zyrtec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Brethine (terbutaline sulfate) and Zyrtec (cetirizine hydrochloride). Common drug interactions include amnesia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Brethine and Zyrtec. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Brethine?

Brethine has active ingredients of terbutaline sulfate. eHealthMe is studying from 480 Brethine users. Check the latest studies of Brethine.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,619 Zyrtec users. Check the latest studies of Zyrtec.



On Jul, 19, 2026

17 people who take Brethine and Zyrtec together, and have interactions are studied.

Brethine and Zyrtec drug interactions.

What are the common drug interactions of Brethine and Zyrtec, by gender? *:

female:

  1. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  2. Drug dependence
  3. Anger
  4. Dyspnoea (difficult or laboured respiration)
  5. Exacerbation of anxiety (increase in the severity of anxiety)
  6. Sedation
  7. Sinusitis (inflammation of sinus)
  8. Breast pain
  9. Earache (ear pain)
  10. Headache (pain in head)

male:

  1. Anxiety
  2. Brain neoplasm (tumour of brain)
  3. Pneumonia
  4. Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
  5. Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
  6. Respiratory distress (difficulty in breathing)
  7. Respiratory syncytial virus infection (viral disease of respiratory system)
  8. Cardiac failure congestive
  9. Chordee (a condition in which the head of the penis curves downward or upward, at the junction of the head)
  10. Feeding disorder neonatal (when newborn refuse to drink milk)

What are the common drug interactions of Brethine and Zyrtec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  2. Drug dependence
  3. Anger
  4. Exacerbation of anxiety (increase in the severity of anxiety)
  5. Sedation
  6. Anxiety
  7. Drug effect decreased
  8. Hypersomnia (excessive daytime sleepiness (eds))
  9. Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
  10. Aggression

40-49:

  1. Asthenia (weakness)
  2. Asthma
  3. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
  4. Dyspnoea (difficult or laboured respiration)
  5. Hot flush (sudden feelings of heat)
  6. Hyperlipidaemia (presence of excess lipids in the blood)
  7. Increased appetite
  8. Laryngitis (inflammation of the larynx)
  9. Mood swings (an extreme or rapid change in mood)
  10. Muscle spasms (muscle contraction)

50-59:

n/a

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Breast pain
  3. Gynaecomastia (enlargement of the gland tissue of the male breast)
  4. Earache (ear pain)
  5. Headache (pain in head)
  6. Sinusitis (inflammation of sinus)
  7. Anxiety
  8. Chest pain
  9. Drug effect decreased
  10. Respiratory disorder (respiratory disease)

What are the existing conditions these people have? *

  1. Stress And Anxiety: 2 people, 11.76%
  2. Nausea (feeling of having an urge to vomit): 2 people, 11.76%
  3. Ill-Defined Disorder: 2 people, 11.76%
  4. Blood Disorder: 2 people, 11.76%
  5. Premature Labor: 1 person, 5.88%
  6. Osteoporosis (bones weak and more likely to break): 1 person, 5.88%
  7. Acute Severe Asthma: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Brethine and Zyrtec?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Brethine and Zyrtec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Brethine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zyrtec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Brethine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zyrtec and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on terbutaline sulfate and cetirizine hydrochloride (the active ingredients of Brethine and Zyrtec, respectively), and Brethine and Zyrtec (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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