Busulfan and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Busulfan (busulfan) and Profen (ibuprofen). Common drug interactions include hepatobiliary disease among females and thrombocytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Busulfan and Profen. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Busulfan?

Busulfan has active ingredients of busulfan. eHealthMe is studying from 14,527 Busulfan users. Check the latest studies of Busulfan.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 15, 2026

13 people who take Busulfan and Profen together, and have interactions are studied.

What are the common drug interactions of Busulfan and Profen, by gender? *:

female:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Erythema multiforme (a type of hypersensitivity reaction)
Fall
Haematocrit decreased
Haematoma (collection of blood outside the blood vessels)
Haemoglobin decreased
Multi-organ failure (multisystem organ failure)
Cytomegalovirus infection
Diffuse alveolar damage (common manifestation of drug-induced lung injury)
Fatigue (feeling of tiredness)

male:

Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Psychotic disorder
Pulmonary embolism (blockage of the main artery of the lung)
Pulseless electrical activity
Sudden cardiac death
Ventricular extrasystoles (premature cardiac contraction)
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

What are the common drug interactions of Busulfan and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Erythema multiforme (a type of hypersensitivity reaction)
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Cytomegalovirus infection
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)

10-19:

n/a

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Diffuse alveolar damage (common manifestation of drug-induced lung injury)
Fatigue (feeling of tiredness)
Feeling hot
Hypoaesthesia (reduced sense of touch or sensation)
Injection site erythema (redness at injection site)
Injection site reaction
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

30-39:

n/a

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Erythema (redness of the skin)
Hypokalaemia (low potassium)
Periorbital oedema (swelling around the eyes)
Pruritus (severe itching of the skin)
Renal failure acute (rapid kidney dysfunction)

50-59:

Haematotoxicity (toxins that destroy red blood cells)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)

60+:

Anaemia (lack of blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Pulmonary embolism (blockage of the main artery of the lung)
Pulseless electrical activity
Sudden cardiac death
Thrombocytopenia (decrease of platelets in blood)
Ventricular extrasystoles (premature cardiac contraction)
Fall
Haematocrit decreased
Haematoma (collection of blood outside the blood vessels)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 23.08%
Fever: 3 people, 23.08%
Lymphoma (cancer that begins in immune system cells): 3 people, 23.08%
Dehydration (dryness resulting from the removal of water): 2 people, 15.38%
Diarrhea: 2 people, 15.38%
Febrile Neutropenia (fever with reduced white blood cells): 2 people, 15.38%
Constipation: 2 people, 15.38%
Fluid Overload (too much fluid in the blood): 2 people, 15.38%
Fungal Infection: 2 people, 15.38%
Mucosal Inflammation (infection of mucous membrane): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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