Bydureon and Advil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Bydureon (exenatide synthetic) and Advil (ibuprofen). Common drug interactions include injection site haemorrhage among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Bydureon and Advil. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Bydureon?

Bydureon has active ingredients of exenatide synthetic. It is often used in type 2 diabetes. eHealthMe is studying from 24,309 Bydureon users. Check the latest studies of Bydureon.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,534 Advil users. Check the latest studies of Advil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

31 people who take Bydureon and Advil together, and have interactions are studied.

What are the common drug interactions of Bydureon and Advil, by gender? *:

female:

Injection site haemorrhage (bleeding from injection site)
Injection site pain
Chronic kidney disease
Injection site swelling
Injection site pruritus (severe itching at injection site)
Abdominal distension
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Injection site erythema (redness at injection site)

male:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Injection site pruritus (severe itching at injection site)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abdominal distension
Angiopathy (generic term for a disease of the blood vessels)
Anxiety
Appendicitis (inflammation of the appendix)
Cardiomegaly (increased size of heart than normal)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

What are the common drug interactions of Bydureon and Advil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Anxiety
Decreased appetite
Diarrhoea
Dyspepsia (indigestion)
Hyperhidrosis (abnormally increased sweating)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site haemorrhage (bleeding from injection site)
Injection site induration

40-49:

Abdominal distension
Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Discomfort
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pharyngeal disorder
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Weight increased

50-59:

Injection site pruritus (severe itching at injection site)
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Injection site pain
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)

60+:

Injection site haemorrhage (bleeding from injection site)
Chronic kidney disease
Decreased appetite
Diarrhoea
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart valve replacement
Hip fracture
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 19.35%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 9.68%
Oedema (fluid collection in tissue): 3 people, 9.68%
Asthma: 3 people, 9.68%
Weight Decreased: 2 people, 6.45%
Neuropathy Peripheral (surface nerve damage): 2 people, 6.45%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.45%
Hypotension (abnormally low blood pressure): 2 people, 6.45%
High Blood Cholesterol: 2 people, 6.45%
Diabetes: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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