Caffeine citrate and Seroquel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Caffeine citrate (caffeine citrate) and Seroquel (quetiapine fumarate). Common drug interactions include abdominal pain upper among females and acidosis among males.

The phase IV clinical study analyzes what interactions people have when they take Caffeine citrate and Seroquel. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Caffeine citrate?

Caffeine citrate has active ingredients of caffeine citrate. It is often used in fatigue. eHealthMe is studying from 2,424 Caffeine citrate users. Check the latest studies of Caffeine citrate.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.



On Jul, 28, 2026

36 people who take Caffeine citrate and Seroquel together, and have interactions are studied.

Caffeine citrate and Seroquel drug interactions.

What are the common drug interactions of Caffeine Citrate and Seroquel, by gender? *:

female:

  1. Abdominal pain upper
  2. Dizziness
  3. Dry mouth
  4. Hypersensitivity
  5. Oedema peripheral (superficial swelling)
  6. Stomatitis (inflammation of mucous membrane of mouth)
  7. Weight increased
  8. Arthralgia (joint pain)
  9. Asthenia (weakness)
  10. Blood cholesterol increased

male:

  1. Acidosis (build-up of carbon dioxide in the blood)
  2. Hypokalaemia (low potassium)
  3. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
  4. Hypotension (abnormally low blood pressure)
  5. Paralysis
  6. Vomiting

What are the common drug interactions of Caffeine Citrate and Seroquel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Vomiting
  2. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  3. Dizziness
  4. Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)
  5. Nausea (feeling of having an urge to vomit)
  6. Overdose

30-39:

n/a

40-49:

  1. Knee arthroplasty
  2. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
  3. Sinusitis (inflammation of sinus)
  4. Weight decreased
  5. Adverse drug reaction
  6. Adverse event
  7. Alopecia (absence of hair from areas of the body)
  8. Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
  9. Abdominal discomfort
  10. Hypersensitivity

50-59:

  1. Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
  2. Muscle spasms (muscle contraction)
  3. Nausea (feeling of having an urge to vomit)
  4. Pruritus (severe itching of the skin)
  5. Rash macular (small, flat red spots)
  6. Somnolence (a state of near-sleep, a strong desire for sleep)
  7. Tremor (trembling or shaking movements in one or more parts of your body)
  8. Vision blurred
  9. Weight increased
  10. Abdominal pain upper

60+:

  1. Acidosis (build-up of carbon dioxide in the blood)
  2. Hypokalaemia (low potassium)
  3. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
  4. Hypotension (abnormally low blood pressure)
  5. Paralysis

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 31 people, 86.11%
  2. Stress And Anxiety: 11 people, 30.56%
  3. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 19.44%
  4. Indigestion: 6 people, 16.67%
  5. Psoriasis (immune-mediated disease that affects the skin): 4 people, 11.11%
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 5.56%
  7. Inflammation: 2 people, 5.56%
  8. Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Caffeine citrate and Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Caffeine citrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Caffeine citrate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Seroquel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on caffeine citrate and quetiapine fumarate (the active ingredients of Caffeine citrate and Seroquel, respectively), and Caffeine citrate and Seroquel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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