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Caffeine and Azelastine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Caffeine (caffeine) and Azelastine (azelastine hydrochloride). Common drug interactions include secretion discharge among females and hospitalisation among males.

The phase IV clinical study analyzes what interactions people have when they take Caffeine and Azelastine. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

What is Azelastine?

Azelastine has active ingredients of azelastine hydrochloride. It is often used in allergies. eHealthMe is studying from 17,399 Azelastine users. Check the latest studies of Azelastine.

On Jul, 07, 2026

21 people who take Caffeine and Azelastine together, and have interactions are studied.

Caffeine and Azelastine drug interactions.

What are the common drug interactions of Caffeine and Azelastine, by gender? *:

female:

  1. Secretion discharge
  2. Small intestinal obstruction (blockage in small intestine)
  3. Squamous cell carcinoma (a cancer of a kind of epithelial cell)
  4. Streptococcal infection
  5. Stress
  6. Tendon rupture (tear of tendon)
  7. Thyroid mass
  8. Vertigo
  9. Vomiting
  10. Weight decreased

male:

  1. Hospitalisation
  2. Anxiety
  3. Dissociative disorder
  4. Drug ineffective
  5. Dyslipidaemia (abnormal amount of lipids)
  6. Dyspnoea (difficult or laboured respiration)
  7. Facial paralysis (loss of function of face muscle)
  8. Hypersensitivity
  9. Hypoaesthesia (reduced sense of touch or sensation)
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

What are the common drug interactions of Caffeine and Azelastine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Anger
  2. Anxiety
  3. Asthma
  4. Attention deficit/hyperactivity disorder
  5. Chest pain
  6. Dissociative disorder
  7. Dyspnoea (difficult or laboured respiration)
  8. Hypoaesthesia (reduced sense of touch or sensation)
  9. Nightmare (unpleasant dream)
  10. Palpitations (feelings or sensations that your heart is pounding or racing)

20-29:

  1. Cough
  2. Injection site pain
  3. Pain
  4. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  5. Peripheral swelling
  6. Secretion discharge

30-39:

  1. Affective disorder (mental disorder)
  2. Headache (pain in head)
  3. Arthralgia (joint pain)

40-49:

  1. Hospitalisation
  2. Anxiety
  3. Dyslipidaemia (abnormal amount of lipids)
  4. Hypersensitivity
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
  6. Impaired gastric emptying
  7. Loss of consciousness
  8. Upper limb fracture
  9. Weight decreased

50-59:

  1. Dizziness
  2. Nausea (feeling of having an urge to vomit)
  3. Abdominal discomfort
  4. Anxiety
  5. Asthma
  6. Back pain
  7. Bacterial infection
  8. Blood pressure decreased
  9. Cardiac flutter (abnormal heart rhythm)
  10. Chills (felling of cold)

60+:

  1. Sinusitis (inflammation of sinus)
  2. Upper respiratory tract infection
  3. Decreased appetite
  4. Dizziness
  5. Drug ineffective
  6. Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
  7. Enterocolitis infectious
  8. Eye irritation
  9. Eye pruritus (eye itching)
  10. Facial paralysis (loss of function of face muscle)

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 4 people, 19.05%
  2. Asthma: 4 people, 19.05%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 14.29%
  4. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 14.29%
  5. Psoriasis (immune-mediated disease that affects the skin): 2 people, 9.52%
  6. Hypersensitivity: 2 people, 9.52%
  7. Drowsiness: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Caffeine and Azelastine?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Caffeine and Azelastine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Caffeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Azelastine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Caffeine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Azelastine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on caffeine and azelastine hydrochloride (the active ingredients of Caffeine and Azelastine, respectively), and Caffeine and Azelastine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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