Calan and Paxil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Calan (verapamil hydrochloride) and Paxil (paroxetine hydrochloride). Common drug interactions include palpitations among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Calan and Paxil. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Calan?

Calan has active ingredients of verapamil hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 3,916 Calan users. Check the latest studies of Calan.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

On Jul, 06, 2026

80 people who take Calan and Paxil together, and have interactions are studied.

What are the common drug interactions of Calan and Paxil, by gender? *:

female:

Palpitations (feelings or sensations that your heart is pounding or racing)
Sedation
Type 2 diabetes mellitus
Vomiting
Abdominal pain upper
Affective disorder (mental disorder)
Agitation (state of anxiety or nervous excitement)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arteriosclerosis (thickening and hardening of arteries)
Asthenia (weakness)

male:

Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Insomnia (sleeplessness)
Rash
Renal failure (kidney dysfunction)
Abdominal pain
Atelectasis (partial or complete collapse of the lung)
Atrioventricular block complete (heart block complete)

What are the common drug interactions of Calan and Paxil, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Talipes

2-9:

n/a

10-19:

n/a

20-29:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Affective disorder (mental disorder)
Agitation (state of anxiety or nervous excitement)
Arteriosclerosis (thickening and hardening of arteries)
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Drug ineffective
Folliculitis (infection of hair root)
Hysterectomy
Insomnia (sleeplessness)
Libido decreased (loss of interest in sex)

30-39:

Asthma
Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)
Tardive dyskinesia (a disorder that involves involuntary movements)
Vomiting

40-49:

Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Back pain
Bipolar disorder (mood disorder)
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiovascular disorder (heart diseases)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

50-59:

Injection site pain
Pruritus (severe itching of the skin)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Rash
Abdominal pain
Asthenia (weakness)
Chest pain
Colon cancer stage iii
Coma (state of unconsciousness lasting more than six hours)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)

60+:

Cardiomegaly (increased size of heart than normal)
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Lung cancer stage unspecified (exc metastatic tumours to lung) (lung cancer spreads to other parts with unspecified stage)
Oedema lower limb (fluid collection in tissue of lower leg)
Oedema upper limb (swelling of arm)
Renal failure (kidney dysfunction)
Right ventricular failure (right half of the heart fails to work)
Sedation
Vomiting

What are the existing conditions these people have? *

Pain: 9 people, 11.25%
Sleep Disorder: 8 people, 10.00%
Stress And Anxiety: 7 people, 8.75%
Nausea (feeling of having an urge to vomit): 5 people, 6.25%
Muscle Spasms (muscle contraction): 4 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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