Carbidopa, levodopa and entacapone and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Carbidopa, levodopa and entacapone (carbidopa; entacapone; levodopa) and Sinemet (carbidopa; levodopa). Common drug interactions include lymphoma among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Carbidopa, levodopa and entacapone and Sinemet. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Carbidopa, levodopa and entacapone?

Carbidopa, levodopa and entacapone has active ingredients of carbidopa; entacapone; levodopa. eHealthMe is studying from 546 Carbidopa, levodopa and entacapone users. Check the latest studies of Carbidopa, levodopa and entacapone.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.



On Jul, 06, 2026

66 people who take Carbidopa, levodopa and entacapone and Sinemet together, and have interactions are studied.

Carbidopa, levodopa and entacapone and Sinemet drug interactions.

What are the common drug interactions of Carbidopa, Levodopa And Entacapone and Sinemet, by gender? *:

female:

  1. Lymphoma (cancer that begins in immune system cells)
  2. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  3. Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
  4. Nonspecific reaction (unspecified reaction)
  5. Rehabilitation therapy
  6. Sedation
  7. Thrombosis (formation of a blood clot inside a blood vessel)
  8. Tinnitus (a ringing in the ears)
  9. Tremor (trembling or shaking movements in one or more parts of your body)
  10. Asthenia (weakness)

male:

  1. Anxiety
  2. Hallucination (an experience involving the perception of something not present)
  3. Drug ineffective
  4. Abdominal pain
  5. Diarrhoea
  6. Dizziness
  7. Dysphagia (a condition in which swallowing is difficult or painful)
  8. Hallucination, auditory (perceiving sounds without auditory stimulus)
  9. Headache (pain in head)
  10. Pneumonia

What are the common drug interactions of Carbidopa, Levodopa And Entacapone and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Confusional state
  2. Drug ineffective
  3. Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

n/a

50-59:

  1. Anxiety
  2. Belligerence (aggressive or warlike behaviour)
  3. Cardiac disorder
  4. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  5. Depressed mood
  6. Lumbar vertebral fracture
  7. Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
  8. Rib fracture
  9. Malaise (a feeling of general discomfort or uneasiness)

60+:

  1. Hallucination (an experience involving the perception of something not present)
  2. Body temperature increased
  3. Diarrhoea
  4. Dizziness
  5. Drug ineffective
  6. Dysphagia (a condition in which swallowing is difficult or painful)
  7. Hallucination, auditory (perceiving sounds without auditory stimulus)
  8. Headache (pain in head)
  9. Pneumonia
  10. Screaming (a long loud piercing cry)

What are the existing conditions these people have? *

  1. Hallucinations (sensations that appear real but are created by your mind): 19 people, 28.79%
  2. Delusion (a false belief or opinion): 10 people, 15.15%
  3. Pain: 7 people, 10.61%
  4. Prostatic Disorder: 5 people, 7.58%
  5. Dementia (madness): 5 people, 7.58%
  6. Psychotic Disorder: 4 people, 6.06%
  7. High Blood Pressure: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Carbidopa, levodopa and entacapone and Sinemet?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Carbidopa, levodopa and entacapone and Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Carbidopa, levodopa and entacapone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Carbidopa, levodopa and entacapone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sinemet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; entacapone; levodopa and carbidopa; levodopa (the active ingredients of Carbidopa, levodopa and entacapone and Sinemet, respectively), and Carbidopa, levodopa and entacapone and Sinemet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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