Cardizem cd and Amaryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cardizem cd (diltiazem hydrochloride) and Amaryl (glimepiride). Common drug interactions include oedema peripheral among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Cardizem cd and Amaryl. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Cardizem cd?

Cardizem cd has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 6,045 Cardizem cd users. Check the latest studies of Cardizem cd.

What is Amaryl?

Amaryl has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 32,259 Amaryl users. Check the latest studies of Amaryl.

On Jul, 06, 2026

96 people who take Cardizem cd and Amaryl together, and have interactions are studied.

Cardizem cd and Amaryl drug interactions.

What are the common drug interactions of Cardizem Cd and Amaryl, by gender? *:

female:

Oedema peripheral (superficial swelling)
Oxygen saturation decreased
Anaemia (lack of blood)
Anxiety
Burning sensation
Confusional state
Dyspnoea exertional (breathlessness or shortness of breath)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Glycosylated haemoglobin increased

male:

Cardiac arrest
Hypoglycaemia (deficiency of glucose in the bloodstream)
Confusion
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Renal failure acute (rapid kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Valvular heart disease (diseases of the heart valves)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

What are the common drug interactions of Cardizem Cd and Amaryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Apnoea (suspension of external breathing)
Bradycardia (abnormally slow heart action)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression
Dyspnoea (difficult or laboured respiration)
Gasping (laboured breathing)
Gastro-oesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gastroenteritis helicobacter (inflammation of stomach and intestine caused by helicobacter infection)

50-59:

Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatocellular damage (liver damage)
Hip fracture
Hypoglycaemic coma (coma due to deficiency of glucose in the bloodstream)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Inappropriate adh secretion
Injury
Insomnia (sleeplessness)
Loss of consciousness
Oedema lower limb (fluid collection in tissue of lower leg)

60+:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Renal failure (kidney dysfunction)
Bradycardia (abnormally slow heart action)
Cardiac arrest
Cardiac failure congestive
Oedema peripheral (superficial swelling)
Weight increased
Confusion
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 15 people, 15.62%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 9 people, 9.38%
High Blood Cholesterol: 7 people, 7.29%
Type 2 Diabetes: 6 people, 6.25%
Depression: 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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