Cardizem and Indomethacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cardizem (diltiazem hydrochloride) and Indomethacin (indomethacin). Common drug interactions include muscular weakness among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Cardizem and Indomethacin. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Cardizem?

Cardizem has active ingredients of diltiazem hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 28,014 Cardizem users. Check the latest studies of Cardizem.

What is Indomethacin?

Indomethacin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 16,884 Indomethacin users. Check the latest studies of Indomethacin.

On Jul, 13, 2026

60 people who take Cardizem and Indomethacin together, and have interactions are studied.

Cardizem and Indomethacin drug interactions.

What are the common drug interactions of Cardizem and Indomethacin, by gender? *:

female:

Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Pain
Pyrexia (fever)
Urinary tract infection
Abdominal distension
Abdominal pain
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Agitation (state of anxiety or nervous excitement)
Anxiety

male:

Dyspnoea (difficult or laboured respiration)
Hot flush (sudden feelings of heat)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Iron deficiency anaemia
Prostatic specific antigen increased
Weight increased
Muscle spasms (muscle contraction)
Prostate cancer recurrent
Faeces discoloured
Thrombocytopenia (decrease of platelets in blood)

What are the common drug interactions of Cardizem and Indomethacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cellulitis (infection under the skin)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Scrotal abscess (pus in scrotum)
Scrotal oedema (swelling of scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Testicular necrosis (damaged testes)
Urinary tract infection
Anal abscess
Anxiety
Chest pain

40-49:

Cardiomyopathy (weakening of the heart muscle)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Snoring
Somnolence (a state of near-sleep, a strong desire for sleep)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Vomiting
Anxiety

50-59:

Gastric ulcer (stomach ulcer)
Gastritis haemorrhagic (inflammation of stomach with bleeding)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Grip strength decreased
Hyperhidrosis (abnormally increased sweating)
Hyporeflexia (a condition of below normal or absent reflexes)
Hypotension (abnormally low blood pressure)
Intervertebral disc disorder (spinal disc disorder)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Diarrhoea
Prostatic specific antigen increased
Chronic kidney disease
Hot flush (sudden feelings of heat)
Melaena (the passage of black, tarry stools)
Muscle spasms (muscle contraction)
Prostate cancer recurrent
Renal failure (kidney dysfunction)
Back pain

What are the existing conditions these people have? *

Pain: 15 people, 25.00%
Prostate Cancer: 11 people, 18.33%
Primary Myelofibrosis (primary disorder of the bone marrow): 11 people, 18.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 16.67%
Muscle Spasms (muscle contraction): 9 people, 15.00%
Hot Flush (sudden feelings of heat): 8 people, 13.33%
Depression: 7 people, 11.67%
High Blood Cholesterol: 7 people, 11.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 11.67%
Nausea (feeling of having an urge to vomit): 5 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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