Cardura and Hctz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cardura (doxazosin mesylate) and Hctz (hydrochlorothiazide). Common drug interactions include tendon rupture among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Cardura and Hctz. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Cardura?

Cardura has active ingredients of doxazosin mesylate. It is often used in high blood pressure. eHealthMe is studying from 20,379 Cardura users. Check the latest studies of Cardura.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

On Jul, 09, 2026

42 people who take Cardura and Hctz together, and have interactions are studied.

What are the common drug interactions of Cardura and Hctz, by gender? *:

female:

Tendon rupture (tear of tendon)
Tendonitis (a condition that causes pain and swelling of tendons)
Thrombosis (formation of a blood clot inside a blood vessel)
Tremor (trembling or shaking movements in one or more parts of your body)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Arthralgia (joint pain)

male:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pneumonia viral
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Anxiety
Balance disorder

What are the common drug interactions of Cardura and Hctz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diarrhoea
Headache (pain in head)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia (reduced sense of touch or sensation)
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Migraine (headache)
Muscle spasms (muscle contraction)

40-49:

Gallbladder disorder
Pulmonary embolism (blockage of the main artery of the lung)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Chronic kidney disease
Renal failure (kidney dysfunction)

50-59:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Dyspnoea (difficult or laboured respiration)

60+:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hair colour changes
Hair disorder
Heart rate decreased
Impaired healing
International normalised ratio increased
Respiratory disorder (respiratory disease)
Toothache (tooth pain)
Visual acuity reduced (reduced clearness of vision)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 16.67%
Pain: 6 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 14.29%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 7.14%
Stress And Anxiety: 3 people, 7.14%
High Blood Cholesterol: 3 people, 7.14%
Diabetes: 3 people, 7.14%
Chest Pain: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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