Carvedilol and Plendil drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Carvedilol (carvedilol) and Plendil (felodipine). Common drug interactions include ear disorder among females and decreased appetite among males.
The phase IV clinical study analyzes what interactions people have when they take Carvedilol and Plendil. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.
What is Carvedilol?
Carvedilol has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 112,649 Carvedilol users. Check the latest studies of Carvedilol.
What is Plendil?
Plendil has active ingredients of felodipine. It is often used in high blood pressure. eHealthMe is studying from 4,990 Plendil users. Check the latest studies of Plendil.
44 people who take Carvedilol and Plendil together, and have interactions are studied.

What are the common drug interactions of Carvedilol and Plendil, by gender? *:
female:
- Ear disorder
- Blood glucose decreased
- Limb injury
- Loss of consciousness
- Mobility decreased (ability to move is reduced)
- Muscular weakness (muscle weakness)
- Scratch
- Urinary incontinence (inability to control the flow of urine and involuntary urination)
- Cystitis (inflammation of the wall of the bladder)
- Depression
male:
- Decreased appetite
- Fatigue (feeling of tiredness)
- Heparin-induced thrombocytopenia
- Pain
- Pyrexia (fever)
- Back pain
- Diarrhoea
- Dry skin
- Dyspnoea (difficult or laboured respiration)
- Hypotension (abnormally low blood pressure)
What are the common drug interactions of Carvedilol and Plendil, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Anaemia (lack of blood)
- Aphasia (damage to the parts of the brain that control language)
- Dyspnoea (difficult or laboured respiration)
- Kidney transplant rejection
- Pneumonia
- Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
- Postoperative abscess
- Renal tubular necrosis (death of kidney tubules)
40-49:
- Oedema peripheral (superficial swelling)
- Proteinuria (presence of protein in the urine)
- Pulmonary embolism (blockage of the main artery of the lung)
50-59:
- Acute stress disorder
- Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
- Anoxic encephalopathy (brain damage due to lack of oxygen)
- Blood alkaline phosphatase increased
- Cardiac arrest
- Dyspnoea (difficult or laboured respiration)
- Gamma-glutamyltransferase increased
- Loss of consciousness
- Malaise (a feeling of general discomfort or uneasiness)
- Nasopharyngitis (inflammation of the nasopharynx)
60+:
- Productive cough
- Pain
- Gait disturbance
- Glaucoma (increased fluid pressure in the eye with vision loss)
- Limb discomfort (discomfort in leg)
- Malaise (a feeling of general discomfort or uneasiness)
- Oropharyngeal discomfort (pain or irritation of oropharynx)
- Oropharyngeal pain
- Blood glucose increased
- Blood pressure decreased
What are the existing conditions these people have? *
- Brain Neoplasm (tumour of brain): 9 people, 20.45%
- Indigestion: 8 people, 18.18%
- Osteoporosis (bones weak and more likely to break): 6 people, 13.64%
- Depression: 6 people, 13.64%
- Constipation: 5 people, 11.36%
- Nausea And Vomiting: 5 people, 11.36%
- High Blood Cholesterol: 5 people, 11.36%
- Pain: 5 people, 11.36%
- Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 4 people, 9.09%
- Anaesthesia: 4 people, 9.09%
* Approximation only. Some reports may have incomplete information.
Do you take Carvedilol and Plendil?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Carvedilol (112,649 reports)
- Plendil (4,990 reports)
Browse all drug interactions of Carvedilol and Plendil:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Carvedilol:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Plendil:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Carvedilol and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Plendil and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on carvedilol and felodipine (the active ingredients of Carvedilol and Plendil, respectively), and Carvedilol and Plendil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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