Carvedilol and Silymarin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Carvedilol (carvedilol) and Silymarin (milk thistle). Common drug interactions include contusion among females and aspartate aminotransferase increased among males.
The phase IV clinical study analyzes what interactions people have when they take Carvedilol and Silymarin. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.
What is Carvedilol?
Carvedilol has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 112,649 Carvedilol users. Check the latest studies of Carvedilol.
What is Silymarin?
Silymarin has active ingredients of milk thistle. eHealthMe is studying from 793 Silymarin users. Check the latest studies of Silymarin.
12 people who take Carvedilol and Silymarin together, and have interactions are studied.

What are the common drug interactions of Carvedilol and Silymarin, by gender? *:
female:
- Contusion (a type of hematoma of tissue in which capillaries)
- Diarrhoea
- Vision blurred
- Vitreous haemorrhage (intraocular (inside the eye) bleeding)
male:
- Aspartate aminotransferase increased
- Diarrhoea
- Hepatocellular carcinoma (liver cancer)
- Haematemesis (vomiting of blood)
- Melaena (the passage of black, tarry stools)
- Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
- Gastroenteritis (inflammation of stomach and intestine)
- Hepatic failure (liver failure)
- Hypokalaemia (low potassium)
- Liver carcinoma ruptured (ruptured liver cancer tumour)
What are the common drug interactions of Carvedilol and Silymarin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Aspartate aminotransferase increased
- Diarrhoea
- Hepatic failure (liver failure)
- Hypokalaemia (low potassium)
- Liver carcinoma ruptured (ruptured liver cancer tumour)
- Abdominal pain
50-59:
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
- Pancreatic carcinoma (pancreatic cancer)
- Anaemia (lack of blood)
60+:
- Cardiogenic shock (inadequate circulation of blood)
- Hepatocellular carcinoma (liver cancer)
- Haematemesis (vomiting of blood)
- Melaena (the passage of black, tarry stools)
- Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
- Contusion (a type of hematoma of tissue in which capillaries)
- Gastroenteritis (inflammation of stomach and intestine)
- Vision blurred
- Vitreous haemorrhage (intraocular (inside the eye) bleeding)
What are the existing conditions these people have? *
- Abdominal Pain: 7 people, 58.33%
- Nausea (feeling of having an urge to vomit): 6 people, 50.00%
- Weakness: 4 people, 33.33%
- Liver Carcinoma Ruptured (ruptured liver cancer tumour): 4 people, 33.33%
- Headache (pain in head): 4 people, 33.33%
- Hepatic Failure (liver failure): 4 people, 33.33%
- Hepatic Neoplasm Malignant (liver cancer): 4 people, 33.33%
- Hepatitis B: 4 people, 33.33%
- Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 4 people, 33.33%
- Gastritis (inflammation of stomach): 4 people, 33.33%
* Approximation only. Some reports may have incomplete information.
Do you take Carvedilol and Silymarin?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Carvedilol (112,649 reports)
- Silymarin (793 reports)
Browse all drug interactions of Carvedilol and Silymarin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Carvedilol:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Silymarin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Carvedilol and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Silymarin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on carvedilol and milk thistle (the active ingredients of Carvedilol and Silymarin, respectively), and Carvedilol and Silymarin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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