Cataflam and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cataflam (diclofenac potassium) and Metformin (metformin hydrochloride). Common drug interactions include general physical health deterioration among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Cataflam and Metformin. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Cataflam?

Cataflam has active ingredients of diclofenac potassium. It is often used in pain. eHealthMe is studying from 1,851 Cataflam users. Check the latest studies of Cataflam.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

55 people who take Cataflam and Metformin together, and have interactions are studied.

Cataflam and Metformin drug interactions.

What are the common drug interactions of Cataflam and Metformin, by gender? *:

female:

General physical health deterioration (weak health status)
Heart valve incompetence (heart's valves do not work correctly)
Hepatic cyst
Hepatic steatosis (fatty liver disease)
Hyperchlorhydria (gastric acid levels are higher in stomach)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypersensitivity
Hypotension (abnormally low blood pressure)
Ill-defined disorder
Infection

male:

Drug ineffective
Fatigue (feeling of tiredness)
Urinary tract infection
Abdominal discomfort
Activities of daily living impaired
Arthralgia (joint pain)
Cardiac arrest
Coma (state of unconsciousness lasting more than six hours)
Gait disturbance
Haematemesis (vomiting of blood)

What are the common drug interactions of Cataflam and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hepatic steatosis (fatty liver disease)
Hyperhidrosis (abnormally increased sweating)
Hypothalamo-pituitary disorder (loss of function in an endocrine gland due to failure of the pituitary gland to secrete hormones which stimulate that gland's function)
Insulin-like growth factor increased
Limb injury
Malaise (a feeling of general discomfort or uneasiness)
Nephrolithiasis (calculi in the kidneys)
Road traffic accident
Injection site pain
Adjustment disorder with depressed mood

50-59:

Diabetes mellitus inadequate control
Headache (pain in head)
Thyroid mass
Blood glucose increased
Blood pressure inadequately controlled
Breast disorder female
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Lung infection
Nasopharyngitis (inflammation of the nasopharynx)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)

60+:

Haemorrhage (bleeding)
International normalised ratio increased
Night sweats (sweating in night)
Oedema peripheral (superficial swelling)
Pain in extremity
Parkinson's disease
Pneumonia
Respiratory tract infection
Therapeutic response decreased (less preventive response)
Hypoglycaemia (deficiency of glucose in the bloodstream)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 15 people, 27.27%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 14.55%
High Blood Pressure: 8 people, 14.55%
High Blood Cholesterol: 8 people, 14.55%
Thyroid Diseases: 4 people, 7.27%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 7.27%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 5.45%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 5.45%
Multiple Myeloma (cancer of the plasma cells): 3 people, 5.45%
Inflammation: 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

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