Catapres and Zaroxolyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Catapres (clonidine hydrochloride) and Zaroxolyn (metolazone). Common drug interactions include rash among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Catapres and Zaroxolyn. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Catapres?

Catapres has active ingredients of clonidine hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 6,680 Catapres users. Check the latest studies of Catapres.

What is Zaroxolyn?

Zaroxolyn has active ingredients of metolazone. It is often used in high blood pressure. eHealthMe is studying from 5,244 Zaroxolyn users. Check the latest studies of Zaroxolyn.

On Jul, 18, 2026

82 people who take Catapres and Zaroxolyn together, and have interactions are studied.

Catapres and Zaroxolyn drug interactions.

What are the common drug interactions of Catapres and Zaroxolyn, by gender? *:

female:

Rash
Vomiting
Cardiomegaly (increased size of heart than normal)
Dysphagia (a condition in which swallowing is difficult or painful)
Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)
Abdominal pain
Cardiac failure congestive
Dehydration (dryness resulting from the removal of water)

male:

Pain
Pneumonia
Coronary artery stenosis (narrowing of coronary artery)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Ventricular fibrillation (abnormally irregular heart rhythm)
Headache (pain in head)
Cardiomyopathy (weakening of the heart muscle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the common drug interactions of Catapres and Zaroxolyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pneumonia
Pulmonary toxicity (side effects on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Thrombocytopenia (decrease of platelets in blood)
Drug hypersensitivity
Hypotension (abnormally low blood pressure)
Abdominal pain upper
Acne (skin problems that cause pimples)
Acute respiratory failure
Decreased appetite

30-39:

Anaemia (lack of blood)
Anxiety
Asthenia (weakness)
Cardiomegaly (increased size of heart than normal)
Chest discomfort
Chest pain
Dizziness
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Heart transplant
Hyperkalaemia (damage to or disease of the kidney)

40-49:

Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Pain
Pneumonia
Abdominal pain
Acne (skin problems that cause pimples)
Acute respiratory failure
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anxiety

50-59:

Pneumonia
Acute respiratory failure
Hyperlipidaemia (presence of excess lipids in the blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure congestive
Cellulitis (infection under the skin)
Constipation
Coronary artery stenosis (narrowing of coronary artery)
Ventricular fibrillation (abnormally irregular heart rhythm)
Weight increased

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pain
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin discolouration (change of skin colour)
Skin hypertrophy (skin cells enlarges)
Skin tightness
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

Diabetes: 11 people, 13.41%
Cardiac Disorder: 9 people, 10.98%
Nuclear Magnetic Resonance Imaging Brain: 6 people, 7.32%
High Blood Cholesterol: 6 people, 7.32%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 6 people, 7.32%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 7.32%
Pain: 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

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