Cathflo activase and Levaquin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cathflo activase (alteplase) and Levaquin (levofloxacin). Common drug interactions include injury among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Cathflo activase and Levaquin. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Cathflo activase?

Cathflo activase has active ingredients of alteplase. eHealthMe is studying from 1,469 Cathflo activase users. Check the latest studies of Cathflo activase.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

52 people who take Cathflo activase and Levaquin together, and have interactions are studied.

Cathflo activase and Levaquin drug interactions.

What are the common drug interactions of Cathflo Activase and Levaquin, by gender? *:

female:

Injury
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash
Spinal compression fracture (fracture due to spinal compression on bone)
Tooth abscess (pus formation in tooth)
Breast cancer recurrent
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Constipation

male:

Fatigue (feeling of tiredness)
Gait disturbance
Haematochezia (passage of stools containing blood)
Haemoglobin decreased
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Light chain analysis increased
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)

What are the common drug interactions of Cathflo Activase and Levaquin, by age (0-1 to 60+)? *:

0-1:

Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Ammonia decreased
Anaemia (lack of blood)
Anion gap increased
Aspartate aminotransferase increased
Blast cell count increased
Blood albumin decreased
Blood calcium decreased

2-9:

n/a

10-19:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)

20-29:

Renal failure acute (rapid kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

30-39:

Hospitalisation
Respiratory syncytial virus infection (viral disease of respiratory system)

40-49:

Drug ineffective
Acute respiratory failure
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic calcification (aortic calcification sign of heart valve disease)
Aortic valve incompetence
Arteriosclerosis (thickening and hardening of arteries)

50-59:

Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Light chain analysis increased
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)
Osteoporosis (bones weak and more likely to break)
Pain

60+:

Pericardial effusion (fluid around the heart)
Rash
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
C-reactive protein increased
Constipation
Cyst (a closed sac)
Dental caries
Dysgeusia (disorder of the sense of taste)
Dyspnoea exertional (breathlessness or shortness of breath)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 17 people, 32.69%
Constipation: 16 people, 30.77%
Pain: 15 people, 28.85%
Multiple Myeloma (cancer of the plasma cells): 10 people, 19.23%
Indigestion: 10 people, 19.23%
Fever: 9 people, 17.31%
Insomnia (sleeplessness): 9 people, 17.31%
Pneumonia: 7 people, 13.46%
Nausea And Vomiting: 7 people, 13.46%
Hypersensitivity: 7 people, 13.46%

* Approximation only. Some reports may have incomplete information.

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