Cefazolin and Cefoxitin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cefazolin (cefazolin sodium) and Cefoxitin (cefoxitin sodium). Common drug interactions include abdominal pain among females and cardiomyopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Cefazolin and Cefoxitin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Cefazolin?

Cefazolin has active ingredients of cefazolin sodium. It is often used in infection. eHealthMe is studying from 15,157 Cefazolin users. Check the latest studies of Cefazolin.

What is Cefoxitin?

Cefoxitin has active ingredients of cefoxitin sodium. eHealthMe is studying from 611 Cefoxitin users. Check the latest studies of Cefoxitin.

On Jul, 10, 2026

21 people who take Cefazolin and Cefoxitin together, and have interactions are studied.

Cefazolin and Cefoxitin drug interactions.

What are the common drug interactions of Cefazolin and Cefoxitin, by gender? *:

female:

Abdominal pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Colitis pseudomembranous (antibiotic-associated diarrhoea)
Diarrhoea
Endocarditis staphylococcal (an inflammation of the inner layer of the heart by staphylococcal bacterial infection)
Hepatic steatosis (fatty liver disease)
Hepatitis (inflammation of the liver)
Injury
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

male:

Cardiomyopathy (weakening of the heart muscle)
Pericardial effusion (fluid around the heart)
Blindness
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac failure
Disease recurrence
Erythema multiforme (a type of hypersensitivity reaction)
Eye disorder
Fungal infection
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Cefazolin and Cefoxitin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cardiomyopathy (weakening of the heart muscle)
Pericardial effusion (fluid around the heart)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Anxiety
Blindness
Cardiac failure
Erythema multiforme (a type of hypersensitivity reaction)
Escherichia infection (bacterial infection by escherichia coli)
Eye disorder
Fungal infection

10-19:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Endocarditis staphylococcal (an inflammation of the inner layer of the heart by staphylococcal bacterial infection)
Hepatic steatosis (fatty liver disease)
Hepatitis (inflammation of the liver)
Injury
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure (kidney dysfunction)

20-29:

Leukopenia (less number of white blood cells in blood)
Sepsis (a severe blood infection that can lead to organ failure and death)
Disease recurrence
Escherichia infection (bacterial infection by escherichia coli)

30-39:

Respiratory failure (inadequate gas exchange by the respiratory system)
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)

40-49:

n/a

50-59:

n/a

60+:

Abdominal pain
Colitis pseudomembranous (antibiotic-associated diarrhoea)
Diarrhoea
Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)
Post procedural infection
Procedural pain
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Urethral haemorrhage (urethral bleeding)

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 9 people, 42.86%
Pain: 8 people, 38.10%
Stress And Anxiety: 7 people, 33.33%
Fever: 7 people, 33.33%
Pharyngitis Streptococcal (inflammation of the pharynx caused by infection from. streptococcus): 6 people, 28.57%
Fungaemia (fungi circulate in the blood): 6 people, 28.57%
Pneumonia: 4 people, 19.05%
Staphylococcal Infection (an infection with staphylococcus bacteria): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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