Adderall and Addyi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Addyi (flibanserin). Common drug interactions include vomiting among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall and Addyi. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

What is Addyi?

Addyi has active ingredients of flibanserin. eHealthMe is studying from 1,423 Addyi users. Check the latest studies of Addyi.

On Jul, 10, 2026

16 people who take Adderall and Addyi together, and have interactions are studied.

What are the common drug interactions of Adderall and Addyi, by gender? *:

female:

Vomiting
Anxiety
Confusional state
Abdominal discomfort
Depressed mood
Fatigue (feeling of tiredness)
Feeling jittery
Irritability
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Migraine (headache)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Blunted affect (lack of emotional reactivity)
Dry skin
Erectile dysfunction
Fatigue (feeling of tiredness)
Loss of libido (loss of sexual urge)

What are the common drug interactions of Adderall and Addyi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Vomiting
Arthralgia (joint pain)
Abdominal discomfort
Depressed mood
Feeling jittery
Irritability
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Nightmare (unpleasant dream)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Presyncope

40-49:

Menopause (end of monthly cycles in women)
Nausea (feeling of having an urge to vomit)
Vomiting
Apathy
Fatigue (feeling of tiredness)
Headache (pain in head)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Libido Decreased (loss of interest in sex): 5 people, 31.25%
Drowsiness: 3 people, 18.75%
Thyroid Diseases: 2 people, 12.50%
Stress And Anxiety: 2 people, 12.50%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 12.50%
Menopause (end of monthly cycles in women): 2 people, 12.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 12.50%
Back Pain: 2 people, 12.50%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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