Ceftin and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ceftin (cefuroxime axetil) and Methotrexate (methotrexate sodium). Common drug interactions include abdominal pain among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Ceftin and Methotrexate. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Ceftin?

Ceftin has active ingredients of cefuroxime axetil. It is often used in sinusitis. eHealthMe is studying from 4,333 Ceftin users. Check the latest studies of Ceftin.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 06, 2026

95 people who take Ceftin and Methotrexate together, and have interactions are studied.

Ceftin and Methotrexate drug interactions.

What are the common drug interactions of Ceftin and Methotrexate, by gender? *:

female:

Abdominal pain
Bone pain
Oedema peripheral (superficial swelling)
Pain in jaw
Swelling
Tricuspid valve incompetence (inefficient heart valve)
Colitis ulcerative (inflammation of colon with ulcer)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Renal failure (kidney dysfunction)
Appendicitis (inflammation of the appendix)

male:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Acanthosis (thickening of the skin)
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic valve incompetence
Aortic valve stenosis (narrowing of the aortic valve)

What are the common drug interactions of Ceftin and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dysuria (painful or difficult urination)
Pyrexia (fever)
Septic shock (shock due to blood infection)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)

20-29:

Abdominal discomfort
Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Faeces discoloured
Hypokalaemia (low potassium)

30-39:

n/a

40-49:

Atelectasis (partial or complete collapse of the lung)
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Acute respiratory distress syndrome
Anaphylactic reaction (serious allergic reaction)
Cardiomegaly (increased size of heart than normal)
Dehydration (dryness resulting from the removal of water)
Drug hypersensitivity
Headache (pain in head)
Interstitial lung disease
Psoriasis (immune-mediated disease that affects the skin)

50-59:

Pleural effusion (water on the lungs)
Tricuspid valve incompetence (inefficient heart valve)
Diarrhoea
Appendicitis (inflammation of the appendix)
Aptyalism (deficiency or absence of saliva)
Asthma
Bone disorder
Bone erosion
Bone fragmentation
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)

60+:

Chest pain
Nausea (feeling of having an urge to vomit)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Pyrexia (fever)
Abdominal pain
Anaemia (lack of blood)
Arthralgia (joint pain)
Cough
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 30 people, 31.58%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 28 people, 29.47%
Thrombocytopenia (decrease of platelets in blood): 11 people, 11.58%
Pain: 9 people, 9.47%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 9.47%
High Blood Pressure: 8 people, 8.42%
Stress And Anxiety: 6 people, 6.32%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 5.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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